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Showing 1–8 of 8 results

Advanced filters: Author: Joseph D. Schonhoft Clear advanced filters

Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results

In patients with DNA damage response-deficient solid tumors, the oral ATR kinase inhibitor camonsertib was well tolerated; a recommended phase 2 dose was identified; and encouraging anti-tumor activity was observed, with the highest response rate observed in patients with ovarian cancer.

Timothy A. Yap
Elisa Fontana
Ezra Rosen
ResearchOpen Access05 Jun 2023
Nature Medicine

Volume: 29, P: 1400-1411
Timing facilitated site transfer of an enzyme on DNA

DNA repair proteins require efficient pathways to search for DNA damage lesions within a large genome. Kinetic trapping experiments define the rates of human uracil DNA glycosylase hopping and sliding along damaged DNA substrates and highlight the role of the phosphodiester backbone in DNA sliding.

Joseph D Schonhoft
James T Stivers
Research08 Jan 2012
Nature Chemical Biology

Volume: 8, P: 205-210
Exceptional response to the ATR inhibitor, camonsertib, in a patient with ALT+ metastatic melanoma

Natalie Y. L. Ngoi
Ian M. Silverman
Timothy A. Yap
ResearchOpen Access07 Jul 2025
npj Precision Oncology

Volume: 9, P: 1-7
Author Correction: Circulating tumor cell heterogeneity in neuroendocrine prostate cancer by single cell copy number analysis

Vincenza Conteduca
Sheng-Yu Ku
Himisha Beltran
Amendments and CorrectionsOpen Access13 Sept 2021
npj Precision Oncology

Volume: 5, P: 1-2
Phase 1b study of enzalutamide plus CC-115, a dual mTORC1/2 and DNA-PK inhibitor, in men with metastatic castration-resistant prostate cancer (mCRPC)

Jimmy L. Zhao
Emmanuel S. Antonarakis
Dana Rathkopf
Research18 Nov 2023
British Journal of Cancer

Volume: 130, P: 53-62
Dynamic expression of Schlafen 11 (SLFN11) in circulating tumour cells as a liquid biomarker in small cell lung cancer

Bingnan Zhang
C. Allison Stewart
Carl M. Gay
Research19 Apr 2022
British Journal of Cancer

Volume: 127, P: 569-576
Post-therapy emergence of an NBN reversion mutation in a patient with pancreatic acinar cell carcinoma

Meredith S. Pelster
Ian M. Silverman
Jorge S. Reis-Filho
ResearchOpen Access01 Apr 2024
npj Precision Oncology

Volume: 8, P: 1-7
Circulating tumor cell heterogeneity in neuroendocrine prostate cancer by single cell copy number analysis

Vincenza Conteduca
Sheng-Yu Ku
Himisha Beltran
ResearchOpen Access12 Aug 2021
npj Precision Oncology

Volume: 5, P: 1-8