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Showing 1–8 of 8 results
Advanced filters: Author: Joseph P. Zackular Clear advanced filters

  • Here, the authors provide a framework to map glucuronidated metabolites and show that gut microbes shape their distribution across the body, with findings in mice supported by human data, where colonization and diet influence glucuronidation patterns.

    • Nina R. Boyle
    • Josh J. Sekela
    • Andrew D. Patterson
    ResearchOpen Access
    Nature Communications
    P: 1-21

  • Enterococci enhance the fitness and pathogenesis of Clostridioides difficile in the gut by altering the amino acid composition and providing signals that increase its virulence towards the host.

    • Alexander B. Smith
    • Matthew L. Jenior
    • Joseph P. Zackular
    Research
    Nature
    Volume: 611, P: 780-786

  • We find that bile salt hydrolase N-acyltransferase activity can form bacterial bile acid amidates that are positively correlated with the colonization of gut bacteria that assist in the regulation of the bile acid metabolic network.

    • Bipin Rimal
    • Stephanie L. Collins
    • Andrew D. Patterson
    ResearchOpen Access
    Nature
    Volume: 626, P: 859-863

  • Metagenomics describes the analysis of genetic information in a microbial community to provide taxonomic or functional information on the constituent microorganisms. This Primer describes suitable sample types, sampling handling and processing workflows for metagenomics, and gives a detailed discussion of the various analysis techniques to generate meaningful information from metagenomic data.

    • Shaopeng Liu
    • Judith S. Rodriguez
    • Serghei Mangul
    Reviews
    Nature Reviews Methods Primers
    Volume: 5, P: 1-28

  • Dietary zinc supplements are in common use, but their effect on infection is unclear. New findings now show that excess dietary zinc reduces the diversity of the gut microbiota and increases the susceptibility of antibiotic-treated mice to Clostridium difficile infection.

    • Joseph P Zackular
    • Jessica L Moore
    • Eric P Skaar
    Research
    Nature Medicine
    Volume: 22, P: 1330-1334