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This study provides evidence of a cascading positive tipping point towards electric vehicles, which has occurred or lies within the next few years in lead markets of the EU and China, and potentially the US, and it could spill out into peripheral vehicle marketss across the rest of the world.

Meat products represent a large share of the carbon footprints of cities, which are dependent on the characteristics of supply regions. With spatially explicit data, researchers show how the so-called carbon hoofprint varies between cities due to the different carbon intensities of producing regions.

Residual stresses are pervasive in most modern plastics. Here, the authors show that they promote the migration of low-molecular-weight amorphous polymer and additives from bulk plastics and release micropollutants into water.

Here the authors provide an explanation for 95% of examined predicted loss of function variants found in disease-associated haploinsufficient genes in the Genome Aggregation Database (gnomAD), underscoring the power of the presented analysis to minimize false assignments of disease risk.

The Omicron variant evades vaccine-induced neutralization but also fails to form syncytia, shows reduced replication in human lung cells and preferentially uses a TMPRSS2-independent cell entry pathway, which may contribute to enhanced replication in cells of the upper airway. Altered fusion and cell entry characteristics are linked to distinct regions of the Omicron spike protein.

Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.

High IL1RL1 correlates with poor survival in acute myeloid leukemia. A stress-driven IL-33/IL1RL1 loop induces leukemogenesis and a tolerogenic immune environment. Targeting this axis with bispecific antibodies offers a promising treatment.

A photopolymer platform derived from renewable lipoates can be 3D-printed into high-resolution parts, which possess properties comparable to some commercial acrylic resins, and then recycled to produce a re-printable resin.

The dihydrofolate reductase inhibitor, fluorofolin, shows potent activity against Pseudomonas aeruginosa and selectively eliminates P. aeruginosa from mixed-species bacterial cultures.

High-entropy alloys (HEAs) have interesting properties, but the synthesis of uniform HEAs is challenging. Here design principles are established for the synthesis of core–shell nanoparticles, which can be thermally annealed to produce uniform HEA nanoparticles in a predictable manner.

This paper examines eight individual genomes using a clone-based sequencing approach, for structural variants of 8,000 nucleotides or more. One of the first high-quality inversion maps for the human genome is generated, and it is demonstrated that previous estimates of variation of this sort have been too high.

Dystonia is thought to be driven by impairments in cerebellar signalling. The authors use a mouse genetic approach to silence excitatory transmission in the inferior olive to cerebellum pathway, resulting in dystonia-like signs in the animals which can be alleviated using DBS stimulation of the pathway.

Detection of circulating tumor DNA using MRD-EDGE, a machine-learning-guided single-nucleotide variant and copy-number variant detection platform for signal enrichment, enables monitoring of minimal residual disease and immunotherapy response in settings of low tumor burden.

This protocol describes how to integrate organoids into a vascularized organ-on-a-chip biofabricated platform. The platform is assembled in a 96-well format and allows the connection of two tissues through a single endothelialized microchannel blood vessel.

Yeast central carbon metabolism has been engineered to achieve a more efficient isoprenoid biosynthesis pathway, an advance that brings commodity-scale production of such compounds a step closer.

The GREGoR consortium provides foundational resources and substrates for the future of rare disease genomics.

In a retrospective cohort study examining the comparative effectiveness of diabetes drugs in adults at moderate risk for cardiovascular disease, GLP-1 receptor agonists and SGLT2 inhibitors reduced the risk of cardiovascular events compared to DPP4 inhibitors, whereas sulfonylureas increased the risk.

A genomic constraint map for the human genome constructed using data from 76,156 human genomes from the Genome Aggregation Database shows that non-coding constrained regions are enriched for regulatory elements and variants associated with complex diseases and traits.

An analysis of GPS pedestrian traces shows that (1) people increasingly deviate from the shortest path when the distance between origin and destination increases and that (2) chosen paths are statistically different when origin and destination are swapped. Ultimately, this can explain the observed human attitude in selecting different paths upon return trips.

Miles Parkes and colleagues report results of a large genome-wide association meta-analysis and replication study for Crohn's disease. They identify 30 new susceptibility loci for this inflammatory bowel disease and implicate several interesting candidate genes in disease pathogenesis.

The global rise of drug-resistant bacteria, including those resistant to last-resort antibiotics, poses an urgent health threat. This Review discusses antibiotic re-engineering strategies to increase the activity and improve the efficacy of existing antibiotics against multidrug-resistant infections.

A single-cell approach is used to follow the heritable stochastic changes to DNA methylation that occur in primary chronic lymphocytic leukaemia and healthy B cells, allowing the tracing of cell lineage histories and evolution during treatment with ibrutinib.

This protocol details the preparation of selective organ-targeting lipid nanoparticles by several methods, their physical characterization, and in vitro/in vivo mRNA delivery evaluation.

IBEX (iterative bleaching extends multiplexity) is an iterative immunolabeling and chemical bleaching method that enables highly multiplexed imaging in diverse tissues.

This Perspective overviews the design and fabrication of tissue-mimicking phantom materials for the technical validation of biophotonic instrumentation, and identifies a set of criteria for their standardization.

David Whitcomb, Bernie Devlin and colleagues report the results of a genome-wide association study of pancreatitis. They identify common variants at two loci associated with risk of this disease, including one on the X chromosome that shows strong evidence of interaction with alcohol consumption.

A German version of the Interoceptive Accuracy Scale shows similar psychometric properties to the original English version; interoceptive accuracy is negatively related to anxiety, depressive, and somatoform symptoms as well as neurotic traits.