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Showing 1–5 of 5 results
Advanced filters: Author: Judith H. I. Haarhuis Clear advanced filters
  • Multi-contact 4C (MC-4C) sequencing analyzes multi-way conformations of individual alleles. MC-4C identifies the β-globin superenhancer as a hub that can accommodate two genes simultaneously and shows that CTCF-anchored loops collide in WAPL-depleted cells.

    • Amin Allahyar
    • Carlo Vermeulen
    • Wouter de Laat
    Research
    Nature Genetics
    Volume: 50, P: 1151-1160
  • The link between 3D genome architecture and gene expression is still far from resolved. Here the authors show that loss of the CDK catalytic subunit of the Mediator complex results in heterochromatic silencing, which can be rescued by stabilization of cohesin on chromatin.

    • Judith H. I. Haarhuis
    • Robin H. van der Weide
    • Elzo de Wit
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10
  • PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.

    • Sarah C. Moser
    • Anna Khalizieva
    • Jos Jonkers
    Research
    Nature
    Volume: 645, P: 1071-1080
  • The crystal structure of the SA2–SCC1 subunits of human cohesin in complex with CTCF reveals the molecular basis of the cohesin–CTCF interaction that enables the dynamic regulation of chromatin folding.

    • Yan Li
    • Judith H. I. Haarhuis
    • Daniel Panne
    Research
    Nature
    Volume: 578, P: 472-476