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Showing 1–6 of 6 results
Advanced filters: Author: Judith Y. Altarejos Clear advanced filters

  • Myostatin and activin A are the two primary negative regulators of muscle mass. Blocking these circulating ligands during GLP-1 therapy induces improved body composition through preservation of lean mass and enhanced fat mass loss in obese primates.

    • Jason W. Mastaitis
    • Daniel Gomez
    • Mark W. Sleeman
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-8

  • Fat distribution is associated with cardiometabolic disease, although it has been less well studied than overall obesity. In a multiancestry exome-sequencing study, the authors identified predicted loss-of-function mutations in INHBE associated with favorable fat distribution and protection from type 2 diabetes.

    • Parsa Akbari
    • Olukayode A. Sosina
    • Luca A. Lotta
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • CRISPR-Cas9 is a gene editing tool that can be used to modulate gene expression. Here, the authors report the generation of a mouse model that express all components of the CRISPR-Cas9 guide directed Synergistic Activation Mediator (SAM), demonstrate that gene activation can be achieved with various delivery methods and include generation of a disease model of hypercholesterolemia

    • Charleen Hunt
    • Suzanne A. Hartford
    • Guochun Gong
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • β-adrenergic receptor signalling in adipocytes stimulates energy expenditure via cAMP-dependent increases in lipolysis and fatty-acid oxidation, and this signalling mechanism is thought to be disrupted in obesity. Here, the cAMP-responsive CREB coactivator Crtc3 is shown to promote obesity in mice by attenuating β adrenergic receptor signalling in adipose tissue.

    • Youngsup Song
    • Judith Altarejos
    • Marc Montminy
    Research
    Nature
    Volume: 468, P: 933-939

  • The cyclic AMP-responsive element-binding protein (CREB) is phosphorylated in response to a wide variety of signals, and it functions in concert with cAMP-regulated transcriptional co-activators (CRTCs). CREB and CRTCs mediate the effects of fasting and feeding signals on the expression of metabolic programmes in insulin-sensitive tissues.

    • Judith Y. Altarejos
    • Marc Montminy
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 141-151