Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–15 of 15 results
Advanced filters: Author: Julia Pagan Clear advanced filters

  • To celebrate the journal’s 25th anniversary, we asked 13 researchers to offer a glimpse of what their research field might look like in 2050. They consider how technological breakthroughs — for example, artificial intelligence-powered virtual cells — could transform our understanding of how molecules, organelles and cells behave in different contexts, revolutionize therapies and enable the design of resilient crops.

    • Monther Abu-Remaileh
    • Chii Jou Chan
    • Jan J. Żylicz
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 26, P: 735-740

  • Determining how replication forks move across the human genome is critical for the effective use of agents that target replication stress. Here, the authors present DNAscent, an AI supported assay for DNA replication stress in human cells using Nanopore sequencing data.

    • Mathew J. K. Jones
    • Subash Kumar Rai
    • Michael A. Boemo
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • The mitochondrial phosphatase PPTC7 has previously been linked to the maintenance of mitochondrial content, but the mechanisms underlying this phenotype remain unclear. Here, the authors demonstrate that loss of Pptc7 results in metabolic defects and further suggest that PPTC7 is a regulator of receptor-mediated mitophagy.

    • Natalie M. Niemi
    • Lia R. Serrano
    • David J. Pagliarini
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • A dataset of coding variation, derived from exome sequencing of nearly one million individuals from a range of ancestries, provides insight into rare variants and could accelerate the discovery of disease-associated genes and advance precision medicine efforts.

    • Kathie Y. Sun
    • Xiaodong Bai
    • Suganthi Balasubramanian
    ResearchOpen Access
    Nature
    Volume: 631, P: 583-592

  • Regulatory mechanisms to prevent centriole overduplication during the cell cycle are not completely understood. In this issue, FBXW5 is shown to control the degradation of the centriole assembly factor HsSAS-6. Moreover, the study proposes that FBXW5 is a substrate of both PLK4 and APC/C, two established regulators of centriole duplication.

    • Julia Pagan
    • Michele Pagano
    News & Views
    Nature Cell Biology
    Volume: 13, P: 888-890

  • Inhibition of E3 ubiquitin ligases, which provide substrate specificity to the ubiquitin proteasome system, is an attractive strategy to inhibit the degradation of a small subset of proteins. Skaaret al. discuss the progress that has been made in the development of therapeutic inhibitors of E3 ligases, in particular the SKP1–CUL1–F box protein (SCF) ubiquitin ligase complexes, and the challenges that lie ahead.

    • Jeffrey R. Skaar
    • Julia K. Pagan
    • Michele Pagano
    Reviews
    Nature Reviews Drug Discovery
    Volume: 13, P: 889-903

  • Through their role as substrate adaptors for S phase kinase-associated protein 1 (SKP1)–cullin 1 (CUL1)–F-box protein (SCF) ubiquitin ligase complexes, F-box proteins control the degradation of a large number of proteins with wide-ranging functions. Studying the mechanisms of substrate recruitment by F-box proteins has increased our understanding of their dysregulation in disease and might lead to targeted therapies.

    • Jeffrey R. Skaar
    • Julia K. Pagan
    • Michele Pagano
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 14, P: 369-381

  • PTEN, a known tumour suppressor, inhibits the FXBL2-dependent degradation of IP3R3, an IP3 receptor, thus augmenting IP3R3-mediated calcium release from the endoplasmic reticulum to mitochondria and inducing apoptosis; inhibiting FXBL2 sensitizes PTEN-deficient tumours to photodynamic therapy.

    • Shafi Kuchay
    • Carlotta Giorgi
    • Michele Pagano
    Research
    Nature
    Volume: 546, P: 554-558