Nature Search

Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families

Henry A. Erlich
Adina Zeidler
Jerome I. Rotter
Research01 Apr 1993
Nature Genetics

Volume: 3, P: 358-364
Palaeolithic–Neolithic seed remains at Franchthi Cave, Greece

JULIE HANSEN
JANE M. RENFREW
Research01 Jan 1978
Nature

Volume: 271, P: 349-352
The nuclear lamina is a meshwork of intermediate-type filaments

Ueli Aebi
Julie Cohn
Larry Gerace
Research09 Oct 1986
Nature

Volume: 323, P: 560-564
CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

Alterations in the tumour suppressor genes STK11 and/or KEAP1 can identify patients with advanced non-small-cell lung cancer who are likely to benefit from combinations of PD-(L)1 and CTLA4 immune checkpoint inhibitors added to chemotherapy.

Ferdinandos Skoulidis
Haniel A. Araujo
John V. Heymach
ResearchOpen Access09 Oct 2024
Nature

Volume: 635, P: 462-471
Blinatumomab after R-CHOP bridging therapy for patients with Richter transformation: a phase 2 multicentre trial

A combination of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is a commonly used regimen for patients with Richter transformation (RT), an aggressive lymphoma with a poor prognosis. Here the authors report the results of a phase 2 clinical trial of blinatumomab (an anti-CD3/anti-CD19 bispecific T-cell-engager) after R-CHOP bridging therapy for patients with RT.

Romain Guièze
Loïc Ysebaert
Pierre Feugier
ResearchOpen Access09 Aug 2024
Nature Communications

Volume: 15, P: 1-8
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Isatuximab, lenalidomide, dexamethasone and bortezomib in transplant-ineligible multiple myeloma: the randomized phase 3 BENEFIT trial

In patients with newly diagnosed, transplant-ineligible multiple myeloma, addition of weekly bortzomib to isatuximab, lenalidomide and dexamethasone leads to increased minimal residual disease negativity compared with isatuximab, lenalidomide and dexamethasone.

Xavier Leleu
Cyrille Hulin
Thierry Facon
ResearchOpen Access03 Jun 2024
Nature Medicine

Volume: 30, P: 2235-2241
Author Correction: CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

Ferdinandos Skoulidis
Haniel A. Araujo
John V. Heymach
Amendments and CorrectionsOpen Access27 Feb 2025
Nature

Volume: 639, P: E19
Identification of genes involved in colon cancer metastasis using cDNA microarrays

Priti Hegde
Julie Earle-Hughes
John Quackenbush
Research Highlights01 Nov 1999
Nature Genetics

Volume: 23, P: 50
Immune correlates analysis of the PREVENT-19 COVID-19 vaccine efficacy clinical trial

Authors have previously reported on the efficacy and safety of the recombinant spike protein nanoparticle vaccine, NVX-CoV2373, in healthy adults. In this work, they assess anti-spike binding IgG, anti-RBD binding IgG and neutralising antibody titer as correlates of risk and protection against COVID-19.

Youyi Fong
Yunda Huang
Peter B. Gilbert
ResearchOpen Access19 Jan 2023
Nature Communications

Volume: 14, P: 1-15
An actionable anti-racism plan for geoscience organizations

Racism thrives in geoscience. We present an antiracism plan to support the recruitment, retention and success of Black, Indigenous, and other people of color in geoscience. Our action plan can be adapted by any organization to remove barriers to participation for all marginalized geoscientists.

Hendratta N. Ali
Sarah L. Sheffield
Blair Schneider
ReviewsOpen Access22 Jun 2021
Nature Communications

Volume: 12, P: 1-6
Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer

Small-cell lung cancer (SCLC) is an aggressive disease with limited therapeutic options. Here the authors perform an immunogenomic analysis of limited-stage SCLC, revealing a homogeneous mutational landscape, but limited T-cell infiltration and a cold and heterogeneous T cell repertoire.

Ming Chen
Runzhe Chen
Jianjun Zhang
ResearchOpen Access17 Nov 2021
Nature Communications

Volume: 12, P: 1-13
A new molecular classification to drive precision treatment strategies in primary Sjögren’s syndrome

Sjögren’s syndrome, a disease that primarily affects women, is poorly understood. Here, the authors combine data from a large cohort of patients and healthy controls to identify biomarkers that distinguish patient subgroups to improve our understanding of the disease and facilitate drug development.

Perrine Soret
Christelle Le Dantec
Jacques-Olivier Pers
ResearchOpen Access10 Jun 2021
Nature Communications

Volume: 12, P: 1-18
Publisher Correction: Immune correlates analysis of the PREVENT-19 COVID-19 vaccine efficacy clinical trial

Youyi Fong
Yunda Huang
Peter B. Gilbert
Amendments and CorrectionsOpen Access22 Mar 2023
Nature Communications

Volume: 14, P: 1
Engineering tolerance and hyperaccumulation of arsenic in plants by combining arsenate reductase and γ-glutamylcysteine synthetase expression

Om Parkash Dhankher
Yujing Li
Richard B. Meagher
Research07 Oct 2002
Nature Biotechnology

Volume: 20, P: 1140-1145
Modulating conjunctival wound healing

M Francesca Cordeiro
Lydia Chang
Peng T Khaw
Research01 May 2000
Eye

Volume: 14, P: 536-547
Classification of GBA1 variants and their impact on Parkinson’s disease: an in silico score analysis

Aymeric Lanore
Christelle Tesson
Eva Camgrand
ResearchOpen Access02 Aug 2025
npj Parkinson's Disease

Volume: 11, P: 1-14
Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus

Peter Donnelly and colleagues report a genome-wide association study for Barrett's esophagus, a common premalignant condition associated with stomach acid reflux and predisposing to esophageal adenocarcinoma. They identify two loci associated with susceptibility to Barrett's esophagus.

Zhan Su
Laura J Gay
Janusz A Z Jankowski
Research09 Sept 2012
Nature Genetics

Volume: 44, P: 1131-1136
Ten considerations for effectively managing the COVID-19 transition

Thirty-two experts propose ten considerations for managing the de-escalation of COVID-19 containment measures while still maintaining public adherence to social and physical distancing.

Katrine Bach Habersaat
Cornelia Betsch
Robb Butler
Reviews24 Jun 2020
Nature Human Behaviour

Volume: 4, P: 677-687
Author Correction: Classification of GBA1 variants and their impact on Parkinson’s disease: an in silico score analysis

Aymeric Lanore
Christelle Tesson
Eva Camgrand
Amendments and CorrectionsOpen Access21 Nov 2025
npj Parkinson's Disease

Volume: 11, P: 1
Leveraging deep learning to understand health beliefs about the Human Papillomavirus Vaccine from social media

Jingcheng Du
Rachel M. Cunningham
Cui Tao
ResearchOpen Access15 Apr 2019
npj Digital Medicine

Volume: 2, P: 1-4
Molecular subtypes explain lupus epigenomic heterogeneity unveiling new regulatory genetic risk variants

Olivia Castellini-Pérez
Elena Povedano
Marta E. Alarcón-Riquelme
ResearchOpen Access16 Jul 2024
npj Genomic Medicine

Volume: 9, P: 1-13
Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings

Eva Velthorst
Josephine Mollon
Abraham Reichenberg
Research07 Jan 2021
Molecular Psychiatry

Volume: 26, P: 4529-4543
Association between Adverse Childhood Experiences and long-term outcomes in people at Clinical High-Risk for Psychosis

Stefania Tognin
Ana Catalan
Philip McGuire
ResearchOpen Access20 Feb 2025
Schizophrenia

Volume: 11, P: 1-9
Clinical, cognitive and neuroanatomical associations of serum NMDAR autoantibodies in people at clinical high risk for psychosis

Thomas A. Pollak
Matthew J. Kempton
Philip McGuire
ResearchOpen Access19 Oct 2020
Molecular Psychiatry

Volume: 26, P: 2590-2604
Grb2 regulation of the actin-based cytoskeleton is required for ligand-independent EGF receptor-mediated oncogenesis

Julie L Boerner
Andrew J Danielsen
Nita J Maihle
Research02 Oct 2003
Oncogene

Volume: 22, P: 6679-6689
The N-terminal loop of IRAK-4 death domain regulates ordered assembly of the Myddosome signalling scaffold

Anthony C. G. Dossang
Precious G. Motshwene
Nicholas J. Gay
ResearchOpen Access23 Nov 2016
Scientific Reports

Volume: 6, P: 1-12
Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis

Martin Kerick
Marialbert Acosta-Herrera
Javier Martin
ResearchOpen Access05 Oct 2022
npj Genomic Medicine

Volume: 7, P: 1-12
Integrative epigenomics in Sjögren´s syndrome reveals novel pathways and a strong interaction between the HLA, autoantibodies and the interferon signature

María Teruel
Guillermo Barturen
Marta E. Alarcón-Riquelme
ResearchOpen Access02 Dec 2021
Scientific Reports

Volume: 11, P: 1-18
IgM antibodies against malondialdehyde and phosphorylcholine in different systemic rheumatic diseases

Divya Thiagarajan
Nina Oparina
Johan Frostegård
ResearchOpen Access03 Jul 2020
Scientific Reports

Volume: 10, P: 1-13
Standardization procedure for flow cytometry data harmonization in prospective multicenter studies

Lucas Le Lann
Pierre-Emmanuel Jouve
Michael Zauner
ResearchOpen Access14 Jul 2020
Scientific Reports

Volume: 10, P: 1-8
Protective Policy Index (PPI) global dataset of origins and stringency of COVID 19 mitigation policies

Olga Shvetsova
Andrei Zhirnov
Tianyi Zhao
ResearchOpen Access16 Jun 2022
Scientific Data

Volume: 9, P: 1-10
No impact of CD34⁺ cell dose on outcome among children undergoing autologous hematopoietic stem cell transplant for high-risk neuroblastoma

Tristan E. Knight
Kwang Woo Ahn
Gregory A. Yanik
Correspondence04 Sept 2023
Bone Marrow Transplantation

Volume: 58, P: 1390-1393

Search

Mapping the human genetic architecture of COVID-19

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Whole-genome sequencing reveals host factors underlying critical COVID-19

A second update on mapping the human genetic architecture of COVID-19

HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families

Palaeolithic–Neolithic seed remains at Franchthi Cave, Greece

The nuclear lamina is a meshwork of intermediate-type filaments

CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

Blinatumomab after R-CHOP bridging therapy for patients with Richter transformation: a phase 2 multicentre trial

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Isatuximab, lenalidomide, dexamethasone and bortezomib in transplant-ineligible multiple myeloma: the randomized phase 3 BENEFIT trial

Author Correction: CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

Identification of genes involved in colon cancer metastasis using cDNA microarrays

Immune correlates analysis of the PREVENT-19 COVID-19 vaccine efficacy clinical trial

An actionable anti-racism plan for geoscience organizations

Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer

A new molecular classification to drive precision treatment strategies in primary Sjögren’s syndrome

Publisher Correction: Immune correlates analysis of the PREVENT-19 COVID-19 vaccine efficacy clinical trial

Engineering tolerance and hyperaccumulation of arsenic in plants by combining arsenate reductase and γ-glutamylcysteine synthetase expression

Modulating conjunctival wound healing

Classification of GBA1 variants and their impact on Parkinson’s disease: an in silico score analysis

Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus

Ten considerations for effectively managing the COVID-19 transition

Author Correction: Classification of GBA1 variants and their impact on Parkinson’s disease: an in silico score analysis

Leveraging deep learning to understand health beliefs about the Human Papillomavirus Vaccine from social media

Molecular subtypes explain lupus epigenomic heterogeneity unveiling new regulatory genetic risk variants

Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings

Association between Adverse Childhood Experiences and long-term outcomes in people at Clinical High-Risk for Psychosis

Clinical, cognitive and neuroanatomical associations of serum NMDAR autoantibodies in people at clinical high risk for psychosis

Grb2 regulation of the actin-based cytoskeleton is required for ligand-independent EGF receptor-mediated oncogenesis

The N-terminal loop of IRAK-4 death domain regulates ordered assembly of the Myddosome signalling scaffold

Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis

Integrative epigenomics in Sjögren´s syndrome reveals novel pathways and a strong interaction between the HLA, autoantibodies and the interferon signature

IgM antibodies against malondialdehyde and phosphorylcholine in different systemic rheumatic diseases

Standardization procedure for flow cytometry data harmonization in prospective multicenter studies

Protective Policy Index (PPI) global dataset of origins and stringency of COVID 19 mitigation policies

No impact of CD34⁺ cell dose on outcome among children undergoing autologous hematopoietic stem cell transplant for high-risk neuroblastoma

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