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An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice

Inherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNA^Ala mutation (m.5019A>G) in mice and demonstrate that macrophages carrying this mutation display altered function and metabolism in vitro, along with increased type I IFN release following LPS challenge in vivo.

Eloïse Marques
Stephen P. Burr
Dylan G. Ryan
ResearchOpen Access20 Nov 2025
Nature Communications

Volume: 16, P: 1-24
Defective vascular smooth muscle cell tafazzin impairs mitochondrial function and promotes atherosclerosis in preclinical models

Atherosclerosis is the leading cause of death worldwide. Here, the authors show that defective vascular smooth muscle cell tafazzin promotes mitochondrial dysfunction and atherosclerosis, highlighting tafazzin as a potential therapeutic target.

Cindy Dong
Alison Finigan
Emma Yu
ResearchOpen Access04 Dec 2025
Nature Communications

Volume: 16, P: 1-21
Bcl-wav and the mitochondrial calcium uniporter drive gastrula morphogenesis in zebrafish

Ca²⁺ is an intracellular messenger that has a critical role in zebrafish development. Here Prudent et al. show that during gastrulation, the newly identified Bcl-2 homologue, Bcl-wav and the mitochondrial calcium uniporter regulate cell migration by controlling mitochondrial Ca²⁺storage.

Julien Prudent
Nikolay Popgeorgiev
Germain Gillet
Research14 Aug 2013
Nature Communications

Volume: 4, P: 1-15
Author Correction: Ribonucleotide incorporation into mitochondrial DNA drives inflammation

Amir Bahat
Dusanka Milenkovic
Thomas Langer
Amendments and CorrectionsOpen Access03 Oct 2025
Nature

Volume: 646, P: E31
Cholangiocarcinoma 2026: status quo, unmet needs and priorities

In this Consensus Statement, an international panel of experts present an overview of the latest developments in the field of cholangiocarcinoma. A set of consensus recommendations and research priorities is provided.

Jesus M. Banales
Pedro M. Rodrigues
Victor Lopez-Lopez
Reviews10 Dec 2025
Nature Reviews Gastroenterology & Hepatology

Volume: 23, P: 65-96
Fumarate induces vesicular release of mtDNA to drive innate immunity

Fumarate metabolism regulates the innate immune response through a mechanism in which high levels of fumarate result in the generation of mitochondrial-derived vesicles and the release of mitochondrial DNA into the cytosol, which activates inflammatory pathways.

Vincent Zecchini
Vincent Paupe
Christian Frezza
ResearchOpen Access08 Mar 2023
Nature

Volume: 615, P: 499-506
Ribonucleotide incorporation into mitochondrial DNA drives inflammation

Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.

Amir Bahat
Dusanka Milenkovic
Thomas Langer
ResearchOpen Access24 Sept 2025
Nature

Volume: 647, P: 726-734
SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca²⁺ flux to mitochondria

SMARCA4/2 loss in ovarian and lung cancers is associated with chemotherapy resistance. Here, the authors show that SMARCA4/2 deficiency in cancer cells reduces the expression of the ER-Ca²⁺ channel IP3R3 and subsequently calcium transfer to the mitochondria, which inhibits apoptotic cell death.

Yibo Xue
Jordan L. Morris
Sidong Huang
ResearchOpen Access13 Sept 2021
Nature Communications

Volume: 12, P: 1-17
Author Correction: SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca²⁺ flux to mitochondria

Yibo Xue
Jordan L. Morris
Sidong Huang
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Communications

Volume: 14, P: 1
Activity-dependent compartmentalization of dendritic mitochondria morphology through local regulation of fusion-fission balance in neurons in vivo

The mechanisms regulating mitochondrial architecture in neurons remain unclear. The authors report that in dendrites, mitochondria structure is specified by the CAMKK2-AMPK pathway through compartment-specific and activity-dependent levels of fission.

Daniel M. Virga
Stevie Hamilton
Tommy L. Lewis Jr
ResearchOpen Access08 Mar 2024
Nature Communications

Volume: 15, P: 1-21
Mitochondrial Ca²⁺ uptake controls actin cytoskeleton dynamics during cell migration

Julien Prudent
Nikolay Popgeorgiev
Germain Gillet
ResearchOpen Access09 Nov 2016
Scientific Reports

Volume: 6, P: 1-13
Advancing models of neural development with biomaterials

Human pluripotent stem cell-derived in vitro models have potential as tools to study aspects of human brain development. Here, Heilshorn and colleagues review biomaterial-based approaches that may be integrated into these models in an effort to develop them further and better recapitulate neurodevelopmental processes.

Julien G. Roth
Michelle S. Huang
Sarah C. Heilshorn
Reviews10 Aug 2021
Nature Reviews Neuroscience

Volume: 22, P: 593-615
Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation

Casey et al. explore the basic mechanisms of mitochondrial superoxide production and its impact on interleukin-1β production in LPS-treated macrophages.

Alva M. Casey
Dylan G. Ryan
Michael P. Murphy
ResearchOpen Access19 Feb 2025
Nature Metabolism

Volume: 7, P: 493-507
Molecular mechanisms of mitochondrial dynamics

Mitochondrial fusion and fission events are tightly regulated by core mitochondrial dynamics proteins. Recent structural and functional findings have characterized how these proteins interact with each other, with the mitochondrial membrane and with other organelles to guide membrane remodelling.

Luis-Carlos Tábara
Mayuko Segawa
Julien Prudent
Reviews17 Oct 2024
Nature Reviews Molecular Cell Biology

Volume: 26, P: 123-146
Genome-wide CRISPR/Cas9 screen shows that loss of GET4 increases mitochondria-endoplasmic reticulum contact sites and is neuroprotective

Emma L. Wilson
Yizhou Yu
Emmanouil Metzakopian
ResearchOpen Access11 Mar 2024
Cell Death & Disease

Volume: 15, P: 1-16
Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes

Peroxisomes—tiny intracellular organelles that contain metabolic enzymes—are generated in mammalian cells by the fusion of structures that arise from both mitochondria and the endoplasmic reticulum.

Ayumu Sugiura
Sevan Mattie
Heidi M. McBride
Research01 Feb 2017
Nature

Volume: 542, P: 251-254
Oxygen tension modulates the mitochondrial genetic bottleneck and influences the segregation of a heteroplasmic mtDNA variant in vitro

Using an in vitro culture system, Pezet et al. studied the influence of oxygen on the mitochondrial DNA (mtDNA) in primordial germ cell-like cells (PGCLCs) in vitro. Low oxygen levels resembling in vivo reduced the cell mtDNA content causing a genetic bottleneck and the segregation of different mtDNA genotypes.

Mikael G. Pezet
Aurora Gomez-Duran
Patrick F. Chinnery
ResearchOpen Access14 May 2021
Communications Biology

Volume: 4, P: 1-12
Clinical and laboratory characteristics of symptomatic healthcare workers with suspected COVID-19: a prospective cohort study

Antonin Bal
Karen Brengel-Pesce
Martine Valette
ResearchOpen Access22 Jul 2021
Scientific Reports

Volume: 11, P: 1-10
De-fusing mitochondria defuses the mtDNA time-bomb

Patrick F. Chinnery
Julien Prudent
Research Highlights31 Jul 2019
Cell Research

Volume: 29, P: 781-782
Bcl-2 proteins, cell migration and embryonic development: lessons from zebrafish

J Prudent
N Popgeorgiev
G Gillet
NewsOpen Access15 Oct 2015
Cell Death & Disease

Volume: 6, P: e1910
Publisher Correction: Clinical and laboratory characteristics of symptomatic healthcare workers with suspected COVID-19: a prospective cohort study

Antonin Bal
Karen Brengel-Pesce
Martine Valette
Amendments and CorrectionsOpen Access23 Sept 2021
Scientific Reports

Volume: 11, P: 1-2

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