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A Gamma-adapted subunit vaccine induces broadly neutralizing antibodies against SARS-CoV-2 variants and protects mice from infection

Here the authors show that a Gamma-based subunit vaccine induces broadly neutralizing antibodies against SARS-CoV-2 variants including Omicron, induces cellular immune responses, and protects mice from infection with Omicron BA.5 SARS-CoV-2.

Lorena M. Coria
Juan Manuel Rodriguez
Juliana Cassataro
ResearchOpen Access02 Feb 2024
Nature Communications

Volume: 15, P: 1-14
Effectiveness of an inactivated Covid-19 vaccine with homologous and heterologous boosters against Omicron in Brazil

This study investigates the effectiveness of COVID-19 vaccine boosters following a primary series of CoronaVac vaccination. Using data from Brazil during the Omicron wave, the authors show that boosters provided protection against severe disease, with higher effectiveness from a BNT162b2 than CoronaVac booster.

Otavio T. Ranzani
Matt D. T. Hitchings
Julio Croda
ResearchOpen Access06 Oct 2022
Nature Communications

Volume: 13, P: 1-10
Immune-mediated protection and enhancement of dengue drives patterns of infant cases in Brazil

The burden of dengue disease in infants has increased in Brazil over the last 25 years. Here, the authors analyse spatiotemporal heterogeneity in disease incidence to characterise the contribution of changing maternal immunity to infant dengue risk.

Matt D. T. Hitchings
Angkana T. Huang
Derek A. T. Cummings
ResearchOpen Access06 Feb 2026
Nature Communications

Volume: 17, P: 1-11
Development of bivalent RBD adapted COVID-19 vaccines for broad sarbecovirus immunity

Laura A. Bruno
Celeste Pueblas Castro
Juliana Cassataro
ResearchOpen Access29 May 2025
npj Vaccines

Volume: 10, P: 1-10
Effectiveness of ChAdOx1 vaccine in older adults during SARS-CoV-2 Gamma variant circulation in São Paulo

Here, the authors investigate the effectiveness of the Oxford-AstraZeneca (ChAdOx1) vaccine during extensive Gamma variant SARS-CoV-2 circulation in São Paulo state, Brazil, and find that a two-dose regime is more effective than one dose against mild to severe Covid-19 outcomes in older adults.

Matt D. T. Hitchings
Otavio T. Ranzani
Julio Croda
ResearchOpen Access28 Oct 2021
Nature Communications

Volume: 12, P: 1-8
Epidemiological and clinical characteristics of the COVID-19 epidemic in Brazil

Brazil has one of the fastest-growing COVID-19 epidemics in the world. De Souza et al. report epidemiological, demographic and clinical findings for COVID-19 cases in the country during the first 3 months of the epidemic.

William Marciel de Souza
Lewis Fletcher Buss
Nuno Rodrigues Faria
Research31 Jul 2020
Nature Human Behaviour

Volume: 4, P: 856-865
HTLV infection in Brazil’s second-largest indigenous reserve

Carolina Amianti
Larissa Melo Bandeira
Ana Rita Coimbra Motta-Castro
ResearchOpen Access06 Oct 2022
Scientific Reports

Volume: 12, P: 1-8
Phylogeography and transmission of Mycobacterium tuberculosis spanning prisons and surrounding communities in Paraguay

To role that carceral institutions play in Mycobacterium tuberculosis transmission remains somewhat unknown. Authors perform a prospective genomic surveillance study, to assess transmission dynamics in prisons and surrounding communities in Paraguay.

Gladys Estigarribia Sanabria
Guillermo Sequera
Katharine S. Walter
ResearchOpen Access19 Jan 2023
Nature Communications

Volume: 14, P: 1-10
Serum biomarkers associated with SARS-CoV-2 severity

Fabiani de Morais Batista
Marco Antonio Moreira Puga
Julio Croda
ResearchOpen Access26 Sept 2022
Scientific Reports

Volume: 12, P: 1-9
Spatial and temporal fluctuations in COVID-19 fatality rates in Brazilian hospitals

Analysis of individual-level patient records from Brazil reveals that the extensive shocks in COVID-19 mortality rates are associated with pre-pandemic geographic inequities as well as shortages in healthcare capacity during the pandemic.

Andrea Brizzi
Charles Whittaker
Oliver Ratmann
ResearchOpen Access10 May 2022
Nature Medicine

Volume: 28, P: 1476-1485
Increased incarceration rates drive growing tuberculosis burden in prisons and jeopardize overall tuberculosis control in Paraguay

Víctor Guillermo Sequera
Sarita Aguirre
Alberto L. García-Basteiro
ResearchOpen Access04 Dec 2020
Scientific Reports

Volume: 10, P: 1-7
Author Correction: Spatial and temporal fluctuations in COVID-19 fatality rates in Brazilian hospitals

Andrea Brizzi
Charles Whittaker
Oliver Ratmann
Amendments and CorrectionsOpen Access14 Jul 2022
Nature Medicine

Volume: 28, P: 1509
Genomic epidemiology of the SARS-CoV-2 epidemic in Brazil

The COVID-19 pandemic in Brazil is assessed using phylogenetic and phylogeographic analysis.

Marta Giovanetti
Svetoslav Nanev Slavov
Dimas Tadeu Covas
ResearchOpen Access18 Aug 2022
Nature Microbiology

Volume: 7, P: 1490-1500
Serum vitamin D levels and risk of prevalent tuberculosis, incident tuberculosis and tuberculin skin test conversion among prisoners

Elisangela B. Maceda
Crhistinne C. M. Gonçalves
Julio Croda
ResearchOpen Access17 Jan 2018
Scientific Reports

Volume: 8, P: 1-9
Microfluidic-assisted preparation of RGD-decorated nanoparticles: exploring integrin-facilitated uptake in cancer cell lines

Julio M. Rios De La Rosa
Alice Spadea
Nicola Tirelli
ResearchOpen Access02 Sept 2020
Scientific Reports

Volume: 10, P: 1-15

Search

A Gamma-adapted subunit vaccine induces broadly neutralizing antibodies against SARS-CoV-2 variants and protects mice from infection

Effectiveness of an inactivated Covid-19 vaccine with homologous and heterologous boosters against Omicron in Brazil

Immune-mediated protection and enhancement of dengue drives patterns of infant cases in Brazil

Development of bivalent RBD adapted COVID-19 vaccines for broad sarbecovirus immunity

Effectiveness of ChAdOx1 vaccine in older adults during SARS-CoV-2 Gamma variant circulation in São Paulo

Epidemiological and clinical characteristics of the COVID-19 epidemic in Brazil

HTLV infection in Brazil’s second-largest indigenous reserve

Phylogeography and transmission of Mycobacterium tuberculosis spanning prisons and surrounding communities in Paraguay

Serum biomarkers associated with SARS-CoV-2 severity

Spatial and temporal fluctuations in COVID-19 fatality rates in Brazilian hospitals

Increased incarceration rates drive growing tuberculosis burden in prisons and jeopardize overall tuberculosis control in Paraguay

Author Correction: Spatial and temporal fluctuations in COVID-19 fatality rates in Brazilian hospitals

Genomic epidemiology of the SARS-CoV-2 epidemic in Brazil

Serum vitamin D levels and risk of prevalent tuberculosis, incident tuberculosis and tuberculin skin test conversion among prisoners

Microfluidic-assisted preparation of RGD-decorated nanoparticles: exploring integrin-facilitated uptake in cancer cell lines

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