IL-9-producing CD4 T (Th9) cells have been implicated in allergy and tumor immunity, but how their differentiation is regulated by TGFβ is still unclear. Here the authors show that two transcription factors, DBP and E2F8, institute opposing effects on IL-9 expression downstream of TGFβ/Smad3 linker region-mediated signaling in activated mouse T cells to modulate antitumor responses.
- Sang-A Park
- Yun-Ji Lim
- WanJun Chen
