CD4+ T cells are key drivers of chronic inflammation and immune-mediated tissue damage in autoimmune diseases. Here, the authors employ a mouse model of primary Sjögren disease (pSjD) and identify a subset of CD153+ CD4+ T cells responsible for inflammation and autoimmunity through interactions with CD30+ resident fibroblasts, and demonstrate that targeting the CD153-CD30 axis alleviates disease pathology in mice.
- Kunihiro Otsuka
- Hiroyuki Kondo
- Koji Yasutomo
