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Showing 1–7 of 7 results
Advanced filters: Author: Junuk Lee Clear advanced filters

  • TRPM5 activation requires Ca2+ binding at an S1–S4 pocket in the transmembrane domain (TMD) and a modulatory site in the intracellular domain (ICD). Structural and functional analyses of TRPM5 with Ca2+, the agonist CBTA and the inhibitor triphenylphosphine oxide—all engaging the S1–S4 pocket—reveal how modulation of channel activity is communicated across the TMD and ICD.

    • Zheng Ruan
    • Junuk Lee
    • Wei Lü
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 22, P: 402-410

  • ATP release through large-pore channels is essential for cell communication. Here, the authors reveal how structural flexibility in the PANX1 pore enables selective passage of molecules like ATP and identify mefloquine as a positive modulator acting through a newly identified binding site.

    • Yangyang Li
    • Zheng Ruan
    • Wei Lü
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • Illness signals from the gut reactivate and strengthen flavour representations in the amygdala to support learning from delayed postingestive feedback.

    • Christopher A. Zimmerman
    • Scott S. Bolkan
    • Ilana B. Witten
    ResearchOpen Access
    Nature
    Volume: 642, P: 700-709

  • Midbrain dopamine neurons have been implicated in two related but distinct processes: reward learning and action generation. By combining an operant learning task in mice with recordings from projection-defined dopamine neurons, the authors found that dopamine neurons targeting different parts of the striatum carry different information about rewards and chosen actions.

    • Nathan F Parker
    • Courtney M Cameron
    • Ilana B Witten
    Research
    Nature Neuroscience
    Volume: 19, P: 845-854

  • Integration of chemogenetics with quantitative behavioral assays and whole brain activity mapping reveal how distinct cerebellar regions influence activity during flexible behavioral learning. Integration of chemogenetics with quantitative behavioral assays and whole brain activity mapping reveal how distinct cerebellar regions influence activity during flexible behavioral learning

    • Jessica L. Verpeut
    • Silke Bergeler
    • Samuel S.-H. Wang
    ResearchOpen Access
    Communications Biology
    Volume: 6, P: 1-17