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Showing 1–50 of 110 results

Advanced filters: Author: K Lechner Clear advanced filters

Methylthio-alkane reductases use nitrogenase metalloclusters for carbon–sulfur bond cleavage

Methylthio-alkane reductases are recently discovered enzymes that can produce methanethiol and small hydrocarbons from methylated sulfur compounds. Now the cryo-EM structure of a methylthio-alkane reductase complex is solved, revealing large metalloclusters previously observed only within nitrogenases.

Ana Lago-Maciel
Jéssica C. Soares
Johannes G. Rebelein
ResearchOpen Access23 Oct 2025
Nature Catalysis

Volume: 8, P: 1086-1099
Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target

Lechner et al. used an affinity-based chemical proteomics approach to investigate the target landscape of HDAC inhibitors, and identified an extracellular vesicle regulator MBLAC2 as a universal off-target of 24 hydroxamate inhibitors.

Severin Lechner
Martin Ian P. Malgapo
Guillaume Médard
Research28 Apr 2022
Nature Chemical Biology

Volume: 18, P: 812-820
Chemoproteomic target deconvolution reveals Histone Deacetylases as targets of (R)-lipoic acid

Lipoic acid is a food supplement and approved neuropathy drug but lacks known molecular targets. Here, Lechner et al. employ chemoproteomic target deconvolution to demonstrate that (R)- but not (S)-lipoic acid stereoselectively inhibits histone deacetylases at physiologically achievable doses.

Severin Lechner
Raphael R. Steimbach
Bernhard Kuster
ResearchOpen Access15 Jun 2023
Nature Communications

Volume: 14, P: 1-10
Randomized phase 3 trial of Ropeginterferon alfa-2b versus surveillance after tyrosine kinase inhibitor discontinuation in chronic myeloid leukemia (ENDURE/CML-IX)

Andreas Burchert
Franck E. Nicolini
Christian Michel
ResearchOpen Access12 Jan 2026
Leukemia

P: 1-8
Microtubule-motor activity of a yeast centromere-binding protein complex

A. A. Hyman
K. Middleton
J. Carbon
Research08 Oct 1992
Nature

Volume: 359, P: 533-536
Fractionation of Ribonucleic Acids by ‘Sephadex’ Agarose Gel Electrophoresis

R. VENDRELY
K. ALEXANDROV
Y. COIRAULT
Research20 Apr 1968
Nature

Volume: 218, P: 293-294
Structure of a lasso peptide bound ET_B receptor provides insights into the mechanism of GPCR inverse agonism

Cryo-EM structures reveal how the lasso peptide binds the ET_B receptor, blocking its activation via key hydrophobic interactions. These findings advance lasso peptides as potential drugs for hard-to-treat cancers and GPCR-targeting therapies.

Wataru Shihoya
Hiroaki Akasaka
Osamu Nureki
ResearchOpen Access22 Apr 2025
Nature Communications

Volume: 16, P: 1-11
Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy

Nasopharyngeal carcinoma (NPC) lacks effective diagnostic and therapeutic strategies, in particular at advanced stages. Here, the authors show that expression of the somatostatin receptor 2 is induced by Epstein-Barr virus in NPC and has a key role in the diagnosis, imaging, targeted therapies and prognosis of NPC.

Matt Lechner
Volker H. Schartinger
Valerie J. Lund
ResearchOpen Access05 Jan 2021
Nature Communications

Volume: 12, P: 1-11
Immunocytochemical detection of the multidrug resistance-associated protein and P-glycoprotein in acute myeloid leukemia: impact of antibodies, sample source and disease status

M Filipits
RW Suchomel
R Pirker
Research01 Jul 1997
Leukemia

Volume: 11, P: 1073-1077
Evidence from angle-resolved resonant photoemission for oxygen-2p nature of the Fermi-liquid states in Bi₂CaSr₂Cu₂O₈

T. Takahashi
H. Matsuyama
H. Inokuchi
Research01 Aug 1988
Nature

Volume: 334, P: 691-692
Hypofibrinogenemia in non-M3 acute myeloid leukemia. Incidence, clinical and laboratory characteristics and prognosis

A Weltermann
I Pabinger
K Lechner
Research12 Aug 1998
Leukemia

Volume: 12, P: 1182-1186
Detection of the WT1 transcript by RT-PCR in complete remission has no prognostic relevance in de novo acute myeloid leukemia

A Gaiger
D Schmid
U Jäger
Research08 Dec 1998
Leukemia

Volume: 12, P: 1886-1894
Large clonal expansions of CD8⁺ T cells in acute infectious mononucleosis

Margaret F.C. Callan
Neil Steven
Andrew J. McMichael
Research01 Aug 1996
Nature Medicine

Volume: 2, P: 906-911
Structure determines where crystallization occurs in a soft colloidal glass

Softness, a machine-learned structural quantity, has been recently identified as a parameter that characterizes glassy dynamics. Here, the authors observe devitrification in 3D soft colloidal glasses and find that softness may indicate regions predisposed to crystallization.

Divya Ganapathi
Dibyashree Chakrabarti
Rajesh Ganapathy
Research07 Sept 2020
Nature Physics

Volume: 17, P: 114-120
High levels of MDM2 are not correlated with the presence of wild-type p53 in human malignant mesothelioma cell lines

S Ungar
A Van de Meeren
BI Gerwin
Research01 Nov 1996
British Journal of Cancer

Volume: 74, P: 1534-1540
A portrait of the Higgs boson by the CMS experiment ten years after the discovery

The most up-to-date combination of results on the properties of the Higgs boson is reported, which indicate that its properties are consistent with the standard model predictions, within the precision achieved to date.

A. Tumasyan
W. Adam
A. Zhokin
ResearchOpen Access04 Jul 2022
Nature

Volume: 607, P: 60-68
Measurement of the Higgs boson width and evidence of its off-shell contributions to ZZ production

The CMS Collaboration reports evidence for off-shell Higgs boson contributions in the production of Z boson pairs, and measures the width of the Higgs boson, which is inversely related to its lifetime.

A. Tumasyan
W. Adam
W. Vetens
ResearchOpen Access20 Oct 2022
Nature Physics

Volume: 18, P: 1329-1334
A highly basic histone H4 domain bound to the sharply bent region of nucleosomal DNA

Konstantin K. Ebralidse
Sergei A. Grachev
Andrei D. Mirzabekov
Research28 Jan 1988
Nature

Volume: 331, P: 365-367
Observation of triple J/ψ meson production in proton-proton collisions

The CMS Collaboration reports the study of three simultaneous hard interactions between quarks and gluons in proton–proton collisions. This manifests through the concurrent production of three J/ψ mesons, which consist of a charm-quark–antiquark pair.

A. Tumasyan
W. Adam
W. Vetens
ResearchOpen Access19 Jan 2023
Nature Physics

Volume: 19, P: 338-350
Interventions to Promote Cancer Awareness and Early Presentation: Systematic Review

J Austoker
C Bankhead
A Ramirez
ResearchOpen Access02 Oct 2009
Nature Precedings

P: 1
Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance

Human papillomavirus (HPV) is a known cause of cervical cancer. Here, the authors perform a multi-omic analysis using published cervical squamous cell carcinoma cohorts from the USA, Europe, and SubSaharan Africa and identify two cervical squamous cell carcinoma subtypes that display prognostic differences.

Ankur Chakravarthy
Ian Reddin
Tim R. Fenton
ResearchOpen Access07 Oct 2022
Nature Communications

Volume: 13, P: 1-17
A deep catalogue of protein-coding variation in 983,578 individuals

A dataset of coding variation, derived from exome sequencing of nearly one million individuals from a range of ancestries, provides insight into rare variants and could accelerate the discovery of disease-associated genes and advance precision medicine efforts.

Kathie Y. Sun
Xiaodong Bai
Suganthi Balasubramanian
ResearchOpen Access20 May 2024
Nature

Volume: 631, P: 583-592
Alteration of Sulfation of Glycoconjugates, but Not Sulfate Transport and Intracellular Inorganic Sulfate Content in Cystic Fibrosis Airway Epithelial Cells

Nirupama K Mohapatra
Pi-Wan Cheng
Thomas F Boat
Research01 Jul 1995
Pediatric Research

Volume: 38, P: 42-48
DNA methylation-based classification of central nervous system tumours

An online approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups has been developed to help to improve current diagnostic standards.

David Capper
David T. W. Jones
Stefan M. Pfister
Research14 Mar 2018
Nature

Volume: 555, P: 469-474
Prognostic significance of WT1 gene expression at diagnosis in adult de novo acute myeloid leukemia

D Schmid
G Heinze
A Gaiger
Research01 May 1997
Leukemia

Volume: 11, P: 639-643
Author Correction: Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target

Severin Lechner
Martin Ian P. Malgapo
Guillaume Médard
Amendments and Corrections15 Jul 2022
Nature Chemical Biology

Volume: 18, P: 913
Inhibition of human pancreatic cancer cell (MIA PaCa-2) growth by cholera toxin and 8-chloro-cAMP in vitro

E Ohmura
K Wakai
RK Robins
Research01 Feb 1993
British Journal of Cancer

Volume: 67, P: 279-283
Characterization of keratin and cell cycle protein expression in cell lines from squamous intraepithelial lesions progressing towards a malignant phenotype

S Hietanen
K Syrjänen
S Syrjänen
Research01 Mar 1998
British Journal of Cancer

Volume: 77, P: 766-775
Recurrent DNA copy number changes in 1q, 4q, 6q, 9p, 13q, 14q and 22q detected by comparative genomic hybridization in malignant mesothelioma

A-M Björkqvist
L Tammilehto
S Knuutila
Research01 Feb 1997
British Journal of Cancer

Volume: 75, P: 523-527
17-AAG, an Hsp90 inhibitor, causes kinetochore defects: a novel mechanism by which 17-AAG inhibits cell proliferation

Y Niikura
S Ohta
K Kitagawa
Research27 Feb 2006
Oncogene

Volume: 25, P: 4133-4146
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

A genome-wide association study for lung cancer finds that genetic sequences in the nicotinic acetylcholine receptor subunit gene cluster contribute susceptibility. Interestingly, this susceptibility is not related to smoking status or frequency, and seems to come from a change in an amino acid in the receptor itself.

Rayjean J. Hung
James D. McKay
Paul Brennan
Research03 Apr 2008
Nature

Volume: 452, P: 633-637
The structure of neurofibromin isoform 2 reveals different functional states

Cryo-EM structure of Nf1 protein is reported, revealing closed and open conformations that regulate interaction with Ras oncogene, setting the stage for understanding the mechanistic action of Nf1 and how disease mutations lead to dysfunction.

Andreas Naschberger
Rozbeh Baradaran
Marta Carroni
ResearchOpen Access27 Oct 2021
Nature

Volume: 599, P: 315-319
Chromosomal abnormalities and their correlations with asbestos exposure and survival in patients with mesothelioma

M Tiainen
L Tammilehto
S Knuutila
Research01 Oct 1989
British Journal of Cancer

Volume: 60, P: 618-626
Cost modeling for the GWh-scale production of modern lithium-ion battery cells

Battery production cost models are critical for evaluating cost competitiveness but frequently lack transparency and standardization. A bottom-up approach for calculating the full cost, marginal cost, and levelized cost of various battery production methods is proposed, enriched by a browser-based modular user tool.

Maximilian Lechner
Anna Kollenda
Arno Kwade
ResearchOpen Access03 Nov 2024
Communications Engineering

Volume: 3, P: 1-11
Defective responses of transformed keratinocytes to terminal differentiation stimuli. Their role in epidermal tumour promotion by phorbol esters and by deep skin wounding

E K Parkinson
Reviews01 Oct 1985
British Journal of Cancer

Volume: 52, P: 479-493
Expression of the multidrug resistance-associated protein (MRP) gene in colorectal carcinomas

M Fillpits
RW Suchomel
R Pirker
Research01 Jan 1997
British Journal of Cancer

Volume: 75, P: 208-212
The in vitro genetic effects of fibrous erionite and crocidolite asbestos

K T Kelsey
E Yano
J B Little
Research01 Jul 1986
British Journal of Cancer

Volume: 54, P: 107-114
Molecular mechanisms of kinetochore capture by spindle microtubules

Kozo Tanaka
Naomi Mukae
Tomoyuki U. Tanaka
Research21 Apr 2005
Nature

Volume: 434, P: 987-994
Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity

The authors developed small-molecule inhibitors of STOML3 oligomerization, a membrane protein that interacts with mechanosensitive ion channels, such as Piezo2. One of these molecules was effective in silencing touch receptors and reversed touch-evoked pain associated with nerve injury or diabetic neuropathy.

Christiane Wetzel
Simone Pifferi
Gary R Lewin
Research12 Dec 2016
Nature Neuroscience

Volume: 20, P: 209-218
Complete biosynthesis of cannabinoids and their unnatural analogues in yeast

Genetic engineering of yeast enables the production of cannabinoids and cannabinoid analogues from the simple sugar galactose, without the need to cultivate Cannabis.

Xiaozhou Luo
Michael A. Reiter
Jay D. Keasling
Research27 Feb 2019
Nature

Volume: 567, P: 123-126
Monitoring of minimal residual leukemia in patients with MLL-AF9 positive acute myeloid leukemia by RT-PCR

G Mitterbauer
C Zimmer
C Mannhalter
Research07 Oct 1999
Leukemia

Volume: 13, P: 1519-1524
Leukemic cells with 11q23 translocations express granulocyte colony-stimulating factor (G-CSF) receptor and their proliferation is stimulated with G-CSF

T Inukai
K Sugita
S Nakazawa
Research30 Apr 1998
Leukemia

Volume: 12, P: 382-389
AN IMPROVED METHOD FOR THE PURIFICATION OF INSULIN-LIKE GROWTH FACTORS I AND II

G Enberg
K Florell
K Hall
Research01 Nov 1986
Pediatric Research

Volume: 20, P: 1191
Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3

Paul Brennan, Stephen Chanock and colleagues performed a genome-wide association study for renal carcinoma. They identified two genetic susceptibility loci.

Mark P Purdue
Mattias Johansson
Paul Brennan
Research05 Dec 2010
Nature Genetics

Volume: 43, P: 60-65
Endogenous antioxidant enzymes and glutathione S-transferase in protection of mesothelioma cells against hydrogen peroxide and epirubicin toxicity

K Kinnula
K Linnainmaa
VL Kinnula
Research01 Apr 1998
British Journal of Cancer

Volume: 77, P: 1097-1102
Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism

Li-Yin Hung
Debasish Sen
De’Broski R. Herbert
ResearchOpen Access18 Oct 2018
Mucosal Immunology

Volume: 12, P: 64-76
Phase II trial of dexverapamil and epirubicin in patients with non-responsive metastatic breast cancer

M Lehnert
K Mross
H Kupper
Research01 Apr 1998
British Journal of Cancer

Volume: 77, P: 1155-1163
Author Correction: A portrait of the Higgs boson by the CMS experiment ten years after the discovery

A. Tumasyan
W. Adam
A. Zhokin
Amendments and CorrectionsOpen Access18 Oct 2023
Nature

Volume: 623, P: E4
Publisher Correction: Observation of triple J/ψ meson production in proton-proton collisions

A. Tumasyan
W. Adam
W. Vetens
Amendments and CorrectionsOpen Access12 Dec 2023
Nature Physics

Volume: 20, P: 332
Author Correction: Complete biosynthesis of cannabinoids and their unnatural analogues in yeast

Xiaozhou Luo
Michael A. Reiter
Jay D. Keasling
Amendments and Corrections17 Mar 2020
Nature

Volume: 580, P: E2

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