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Developing heat-resistant dielectric polymers for electrification is challenging due to the inverse relationship between thermal stability and electrical insulation. Using a machine learning-driven approach, the researchers identify and validate high-performance polymers that demonstrate promising thermal resilience and energy density for high-temperature applications.

Hi-C methods for studying 3D genome structure typically require millions of cells and struggle with repetitive regions. Here, authors develop CiFi, combining 3C with PacBio HiFi sequencing, enabling chromatin analysis from as few as 60,000 cells and chromosome-scale assembly from small samples.

Electrogenerated gas bubbles impair the efficiency of electrolysis and require a deeper insight into their dynamics. Here, the authors describe a transport mechanism in which electrolyte droplets from the coalescence of microbubbles are sprayed into H₂ bubbles.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Insights into the behavior of quantum materials are only possible because of the development of suitable experimental probes. Modic et. al. develop the theoretical and experimental basis for resonant torsion magnetometry—a technique to measure anisotropic magnetic responses with high sensitivity.

It is unclear why some ocean island basalts at ‘hotspots’ have low ³He/⁴He ratios similar to mid-ocean ridge basalts. Here, the authors perform convection calculations and show that these isotopic ratios can be reproduced by the episodic entrainment of deep isolated mantle reservoirs into thermal plumes.

A series of dicyanamide-based hybrid organic–inorganic perovskite structures has been shown to melt at temperatures below 300 °C. On melt-quenching, they form glasses that possess coordination bonding and show very low thermal conductivities and moderate electrical conductivities as well as polymer-like thermomechanical properties.

Coordinated X-ray and radio observations reveal that disk winds and jets occur mutually exclusively in 4U 1630–472, providing new observational constraints on the interplay between different modes of outflow in X-ray binaries.

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb⁻¹.

A challenge of magnetically-actuated devices is to obtain different behaviours from each component under the same driving field. Here the authors tune the dipolar interactions between rotors to obtain different rotational behaviours when actuated by a magnetic field leading to complex collective dynamics.

Polygenic risk scores predict the likelihood that an individual will develop a certain cancer, however these are often specific for a given population. Here, the authors show that a risk score developed to assess the risk of breast cancer in European women can also predict risk in Asian populations.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

A CRISPR screen reveals that loss of structural components of the SAGA complex derails hematopoiesis by decoupling epigenetic control. This halts stem cell maturation, triggers a pathogenic interferon program and boosts human MDS-L cell growth.

Using well-calibrated statistical methods the authors jointly analyze Undiagnosed Diseases Network genomes, identifying known and novel disease genes. Software is publicly available to support future cross-cohort rare disease discovery efforts.

Calcite exhibits extreme anisotropy in its infrared properties, resulting in hyperbolic behavior that can support resonances. This study shows that the relative orientation between calcite resonators and crystal axes can be exploited to manipulate the spectrum, polarization, and propagation of infrared light confined by hyperbolic materials.

The XPD/Rad3 helicase, YoaA-χ, helps resolve DNA damage in E. coli. Here, the authors show that single-stranded DNA binding protein (SSB) affects helicase activity in a substrate specific manner. Single molecule experiments show YoaA- χ can pull SSB along DNA while translocating

A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.

Theoretically predicted in 1979, hyper-Raman optical activity is now experimentally observed through chirality conferral from the electromagnetic field of chiral plasmonic gold nanohelices to crystal violet molecules that are achiral, sparking new science at the organic–inorganic interface.

Hyperbolic lattices emulate particle dynamics equivalent to those in negatively curved space, with connections to general relativity. Here, the authors use electric circuits with a novel complex-phase circuit element to simulate hyperbolic graphene with negligible boundary contributions.

Viscous Dirac fluid flow in room-temperature graphene is imaged using quantum diamond magnetometry, revealing a parabolic Poiseuille profile for electron flow in a high-mobility graphene channel near the charge-neutrality point.

A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

Controlling the magnetization of a material is a major goal of spin-based information processing. One extensively studied method is to use spin-currents, generated from charge currents via the spin hall effect, however, the resulting spin polarization is typically limited to in-plane orientations. Here, Hazra et al demonstrate the presence of out-of-plane polarized spin-currents, which arise due to spin swapping at the Mn3Sn/permalloy interface.

Using over 600 genetic matches of elephant tusks from the same individual or close relatives, from 49 ivory seizures across Africa, Wasser et al. reveal the scale, connectivity and movements of transnational criminal organizations that trade in ivory.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

NSF hydrolyzes ATP to disassemble SNARE complexes. Here, the authors find NSF colocalizes with syntaxin nanodomains, reveal disassembly of syntaxin oligomers and other pre-fusion cis-SNARE complexes by NSF, and show how sequential hydrolysis drives disassembly.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

In most compounds, a roughly linear rise in thermal conductivity (k) with pressure (P) is observed. Here, the authors predict boron phosphide exhibits what may be the steepest rise in k with P of any compound followed by a peak and drop in k due to the action of phonon-scattering selection rules.

Vicinity of small bodies might be dangerous to the spacecrafts and to their instrumentation. Here the authors show the operational environment of asteroid Bennu, validate its photometric phase function and demonstrate the accelerating rotational rate due to YORP effect using the data acquired during the approach phase of OSIRIS-REx mission.

Presence of oxygen in the universe can provide information to stellar mass evolution. Here the authors report their method for the measurements of carbon to oxygen ratio and cross-section of the reaction-capture of helium-4 by carbon-12, to produce oxygen-16.

The use of silicon for integrated quantum photonic technologies is currently hindered by the lack of suitable on-demand quantum light sources. Here, the authors fill this gap by demonstrating the creation of single atomic emissive centers in silicon and their efficient coupling with nanophotonic cavities.

Designing efficient, fast and low power consumption phase change memories remains a challenge. Aryana et al. propose a strategy to reduce operating currents by manipulating the interfacial thermal resistance between the phase change unit and the electrodes without incorporating additional insulating layers.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

Laboratory automation, machine learning, and metabolic engineering may be combined to quickly and efficiently build productive microbial strains. Here the authors used these techniques in P. putida to boost isoprenol titers 5-fold over six DBTL cycles while sampling a reduced design space.

Rising demand for ruminant meat and dairy products in developing nations drives increasing GHG and ammonia emissions from livestock. Authors show here that only long-term adoption of global best-practice in sustainable intensification buffered by a short-term coping strategy of green-source trading can offer a way forward.

Although the trivalent actinides are similar to the lanthanide series in terms of chemistry and bonding, their structures and properties can diverge significantly. Here, the authors report a series of complexes of the trivalent actinides Np(III) through Cf(III) along with their lanthanide counterparts using a polarizable non-innocent, sulfur-donor ligand.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

Spin–orbit coupling in graphene is small, which makes controlling spin currents in this otherwise useful spintronic material difficult. Avsar et al.now demonstrate that combining graphene with few-layer tungsten disulphide increases its spin–orbit coupling by three orders of magnitude