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Showing 1–4 of 4 results
Advanced filters: Author: Kailan Sierra-Davidson Clear advanced filters

  • The clinical utility of immune checkpoint inhibitors is limited by immune-related adverse events (irAEs); understanding the mechanisms of irAE development is thus crucial. A study reports that IL-17A-expressing CD4+ T cells were elevated at irAE onset and provides proof of concept for using IL-17A blockade to improve irAEs in two patients.

    • Kailan Sierra-Davidson
    • Genevieve M. Boland
    News & Views
    Nature Cancer
    Volume: 5, P: 1289-1291

  • Fifty-five percent of individuals vaccinated with an attenuated Plasmodium falciparum sporozoite vaccine remained without parasitemia after controlled human malaria infection one year later; immune correlate analysis in humans and non-human primates suggest a role for liver-resident T cells.

    • Andrew S Ishizuka
    • Kirsten E Lyke
    • Robert A Seder
    Research
    Nature Medicine
    Volume: 22, P: 614-623

  • In this Perspective, Holder et al. discuss the limitations of current predictive biomarkers of response to immune checkpoint inhibitors and the need to further explore static, dynamic and patient-specific biomarkers using novel tools, such as machine learning and consortia-level initiatives.

    • Ashley M. Holder
    • Aikaterini Dedeilia
    • Genevieve M. Boland
    Reviews
    Nature Reviews Cancer
    Volume: 24, P: 498-512