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Showing 1–2 of 2 results
Advanced filters: Author: Kailei D. Goodier Clear advanced filters

  • This study reports a post-assembly, reversible crosslinking strategy that enhances lipid nanoparticle (LNP)-mediated mRNA delivery while preserving efficient intracellular release. The resulting crosslinked LNPs enable improved endosomal escape, sustained in vivo expression and robust immune and antitumor responses across multiple clinically relevant LNP platforms.

    • Xiang Liu
    • Yining Zhu
    • Hai-Quan Mao
    Research
    Nature Chemical Engineering
    Volume: 3, P: 112-127

  • Hydrogel materials have emerged as versatile platforms for biomedical applications. Here this group reports an mRNA lipid nanoparticle-incorporated microgel matrix for immune cell recruitment/antigen expression and presentation/cellular interaction thereby eliciting antitumor efficacy with a single dose.

    • Yining Zhu
    • Zhi-Cheng Yao
    • Hai-Quan Mao
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16