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Showing 1–2 of 2 results
Advanced filters: Author: Kalvin K. Nguyen Clear advanced filters

  • Engineering polymerases to synthesize alternative genetic polymers remains a challenging problem in synthetic biology. The current study offers insights into the structural and biochemical changes responsible for improving the fidelity and catalytic activity of a laboratory evolved TNA polymerase.

    • Mohammad Hajjar
    • Victoria A. Maola
    • John C. Chaput
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-14

  • The catalytic power of DNA polymerases for artificial genetic polymer (XNA) synthesis remains underdeveloped. Now, the evolution and structure of an α-l-threofuranosyl nucleic acid polymerase is described that achieves XNA synthesis with ∼1 nt s−1 and >99% template-copying fidelity.

    • Victoria A. Maola
    • Eric J. Yik
    • John C. Chaput
    Research
    Nature Catalysis
    Volume: 7, P: 1173-1185