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Showing 1–6 of 6 results
Advanced filters: Author: Kamir J. Hiam-Galvez Clear advanced filters

  • The tolerogenic activity of type 1 conventional dendritic cells (cDC1s) is determined by EPOR, which is preferentially expressed in cDC1s and induces antigen-specific FOXP3-expressing regulatory T cells.

    • Xiangyue Zhang
    • Christopher S. McGinnis
    • Edgar G. Engleman
    Research
    Nature
    Volume: 650, P: 470-480

  • Schwannomas are regularly treated with radiotherapy, but the molecular effects on these tumours and their microenvironment remain unclear. Here, the authors show that radiotherapy can induce epigenetic reprogramming and immune infiltration in schwannomas, and develop the snARC-seq approach to analyse the epigenomic evolution at the single-cell level.

    • S. John Liu
    • Tim Casey-Clyde
    • David R. Raleigh
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • Patients with mild COVID-19 show a pattern of interferon-stimulated gene (ISG) expression across all major cell types, but in patients with severe disease, antibodies block the production of these ISG-expressing cells.

    • Alexis J. Combes
    • Tristan Courau
    • Matthew F. Krummel
    Research
    Nature
    Volume: 591, P: 124-130

  • Daniel, Yost, Hsiung, et al. generate a single-cell multiomic atlas of T cell exhaustion in chronic viral infection, which reveals molecular programs of exhausted T cell subsets, identifies divergent clonal exhausted T cell differentiation trajectories and nominates TCR signal strength as a driver of clonal fate.

    • Bence Daniel
    • Kathryn E. Yost
    • Ansuman T. Satpathy
    Research
    Nature Immunology
    Volume: 23, P: 1614-1627

  • An improved understanding of tumour immunology and therapy must assess the systemic immune landscape beyond the tumour microenvironment. This Review outlines peripheral immune cell reorganization in response to tumour growth and therapy, their contribution to immunotherapy responses and their potential as diagnostic or predictive biomarkers.

    • Kamir J. Hiam-Galvez
    • Breanna M. Allen
    • Matthew H. Spitzer
    Reviews
    Nature Reviews Cancer
    Volume: 21, P: 345-359