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Showing 1–7 of 7 results
Advanced filters: Author: Kang-Jie Bian Clear advanced filters

  • The efficient construction of trifluoromethylated alkanes bearing a CF3 chiral center is of great importance in organic synthesis. Here, the authors disclose the enantioselective syntheses of α-trifluoromethylated allylic alkanes via reductive trifluoroalkylation.

    • Ruo-Xing Jin
    • Bing-Bing Wu
    • Xi-Sheng Wang
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-8

  • Hydroazidation of alkenes provides a direct entry to alkyl azides which are prevalent structural motifs in medicine development and chemical biology probes. Here the authors report a photocatalytic anti-Markovnikov hydroazidation of alkenes enabled by cooperative ligand-to-metal charge transfer and hydrogen atom transfer.

    • Kang-Jie Bian
    • Shijin Yu
    • Julian G. West
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10

  • Alkene hydrofluoroalkylation offers a promising route to diverse fluoroalkylated compounds but current methods have limitations, such as needing expensive fluoroalkylating reagents. Now, leveraging iron photocatalysis and hydrogen-atom-transfer catalysis, a hydrofluoroalkylation method has been developed that utilizes feedstock chemicals such as trifluoroacetic acid as direct fluoroalkyl radical precursors, providing a redox-neutral, general protocol to introduce fluoroalkyl moieties.

    • Kang-Jie Bian
    • Yen-Chu Lu
    • Julian G. West
    Research
    Nature Chemistry
    Volume: 15, P: 1683-1692

  • The difunctionalization of alkenes allows for efficient construction of molecular complexity. Combining Ligand-to-Metal Charge transfer (LMCT) and Radical Ligand Transfer (RLT), the authors show a photochemical diazidation using iron salts, allowing rapid preparation of vicinal diamines and other privileged synthetic motifs.

    • Kang-Jie Bian
    • Shih-Chieh Kao
    • Julian G. West
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • Methods for the anti-Markovnikov-selective hydrochlorination of unsaturated C–C bonds are limited by the need for stoichiometric reagents, highly oxidizing photocatalysts and multiple synthetic steps. Now the combination of ligand-to-metal charge transfer and hydrogen atom transfer reactivity enables the anti-Markovnikov-selective hydro- and deuterochlorination of unsaturated hydrocarbons using iron photocatalysis.

    • Kang-Jie Bian
    • David Nemoto Jr
    • Julian G. West
    Research
    Nature Synthesis
    Volume: 4, P: 314-326

  • Although the stereochemistry of nickel hydride addition to alkenes is well-explored, the analogous addition to another feedstock, alkynes, is less studied. Here the authors develop a regio- and enantioselective hydroalkylation of alkynes to produce chiral allylic amines, proceeding via migratory insertion of a nickel–alkyl species into an alkyne pi bond.

    • Qian Gao
    • Wei-Cheng Xu
    • Xi-Sheng Wang
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-9