In this Review, Sauer and colleagues outline how microorganisms coordinate common metabolic tasks. By illustrating the information transfer and flux adaptation for key regulatory circuits inEscherichia coli, Bacillus subtilisand yeast, they conclude that cells rely on a few conserved metabolites to report on their global metabolic status and mount appropriate responses.
- Victor Chubukov
- Luca Gerosa
- Uwe Sauer
