Alanine aminotransferase (ALT) activity is an important indicator to determine drug induced liver injury. However, its measurement is limited to centralized laboratories. Muratore, Zhou, and colleagues designed an ALT assay biosensor platform using silicon nanowire field effect transistor arrays. The biosensor could monitor ALT enzyme activity electrically, with comparable precision to spectrophotometric detection. This biosensor platform will enable routine liver function monitoring in settings both inside and outside of the clinic.
- Katherine A. Muratore
- Dan Zhou
- Pritiraj Mohanty
