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Showing 1–7 of 7 results
Advanced filters: Author: Katja Hrovat Clear advanced filters

  • Mechanical loading experiments on osteoblast cultures highlight the importance of non-collagenous bone proteins in major evolutionary shifts in vertebrates and reveal fetuin-A as a key protein for adapting to increased mechanical stress.

    • Saeka Shimochi
    • Clara Brunet
    • Miho Nakamura
    ResearchOpen Access
    Communications Biology
    Volume: 9, P: 1-9

  • The RNA exonuclease REXO2 plays an important role in the degradation of mitochondrial RNA. Authors here describe a dominant negative REXO2 mutation that causes autoinflammatory disease via Type I IFN activation.

    • Elina Idiiatullina
    • Mahmoud Al-Azab
    • Seth L. Masters
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Mutations in the coatomer complex I can result in endoplasmic reticulum stress and inflammatory consequences. Here authors define aberrant activation of the STING immunosensing pathway in a disturbed coatmer complex context and the therapeutic modulation of this axis to counter the associated immunopathology.

    • Annemarie Steiner
    • Katja Hrovat-Schaale
    • Seth L. Masters
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Gain-of-function variants in the gene encoding NLRP3 lead to constitutive inflammasome activation and excessive IL-1β production. In this resource, authors perform functional screening of clinically relevant NLRP3 variants. Structural analysis suggested multiple mechanisms by which variants activate NLRP3 and the identification of pathogenic variants that can sensitize the activation of NLRP3 in response to nigericin and cold temperature exposure.

    • Shouya Feng
    • Matthew C. Wierzbowski
    • Seth L. Masters
    ResearchOpen Access
    Nature Immunology
    Volume: 26, P: 511-523

  • This Review from Masters and colleagues highlights how damage to intracellular organelles is linked to activation of the innate immune system. The authors propose that a better appreciation of such organellar homeostasis could lead to the identification of novel innate immune pathways and have therapeutic implications.

    • Cassandra R. Harapas
    • Elina Idiiatullina
    • Seth L. Masters
    Reviews
    Nature Reviews Immunology
    Volume: 22, P: 535-549