Nature Search

Recurrent pattern completion drives the neocortical representation of sensory inference

Neurons that respond emergently to illusory contours drive pattern completion in V1. Pattern completion in lower cortical areas may therefore mediate perceptual inference by selectively reinforcing activity patterns that match prior expectations.

Hyeyoung Shin
Mora B. Ogando
Hillel Adesnik
ResearchOpen Access15 Sept 2025
Nature Neuroscience

Volume: 28, P: 2319-2329
miR-142 deficit in T cells during blast crisis promotes chronic myeloid leukemia immune escape

Acquired miR-142 deficit in leukemic stem cells has been associated with chronic myeloid leukemia blast crisis. Here the authors show that acquired miR-142 deficit in T cells further enables leukemic stem cells to escape immune surveillance and supports disease growth.

Fang Chen
Dandan Zhao
Bin Zhang
ResearchOpen Access01 Feb 2025
Nature Communications

Volume: 16, P: 1-21
Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis

Evans, Blake, Longworth and colleagues identify and characterize a tumour-suppressive role for microglia that mediate a pro-inflammatory response to restrict brain metastasis in breast cancer.

Katrina T. Evans
Kerrigan Blake
Devon A. Lawson
Research13 Nov 2023
Nature Cell Biology

Volume: 25, P: 1848-1859
Detection of co-infection and recombination cases with Omicron and local Delta variants of SARS-CoV-2 in Vietnam

Nguyen Thu Trang
Trinh Cong Dien
Yacoub Sophie
ResearchOpen Access20 Jun 2024
Scientific Reports

Volume: 14, P: 1-8
Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes

An integrated analysis of de novo and inherited coding variants in 42,607 individuals with autism spectrum disorder identifies 60 risk genes of which five have not previously been associated with neurodevelopmental disorders.

Xueya Zhou
Pamela Feliciano
Wendy K. Chung
ResearchOpen Access18 Aug 2022
Nature Genetics

Volume: 54, P: 1305-1319
Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia

In this work, authors assess airway microbiome dynamics to show bacterial pneumonia in critically ill COVID-19 patients is significantly associated with death, corticosteroid treatment, disruption of the lung microbiome and a distinct pulmonary host response.

Natasha Spottiswoode
Alexandra Tsitsiklis
Charles R. Langelier
ResearchOpen Access29 Oct 2024
Nature Communications

Volume: 15, P: 1-16
Comparison of AI-integrated pathways with human-AI interaction in population mammographic screening for breast cancer

Successful human-AI collaboration could greatly contribute to breast cancer mammographic screening. Here, the authors use a large-scale retrospective mammography dataset to simulate and compare five plausible AI-integrated screening pathways, finding optimal ways in which human-AI collaboration could be implemented in real-world settings.

Helen M. L. Frazer
Carlos A. Peña-Solorzano
Davis J. McCarthy
ResearchOpen Access30 Aug 2024
Nature Communications

Volume: 15, P: 1-12
IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern

COVID-19 can be treated with monoclonal antibodies against SARS-CoV-2, but emerging new variants might show resistance towards existing therapy. Here authors show that anti-SARS-CoV-2 spike human single-chain antibody fragments could gain neutralizing activity against variants of concern upon engineering into a human bispecific antibody.

Matthew R. Chang
Luke Tomasovic
Wayne A. Marasco
ResearchOpen Access03 Oct 2022
Nature Communications

Volume: 13, P: 1-15
Identification of the bacteriophage nucleus protein interaction network

A family of large-genome bacteriophages assembles a protective protein shell around its replicating DNA called the ‘phage nucleus’. Here, Enustun et al. use proteomics to identify a set of proteins associated with the phage nucleus that aid macromolecule transport through the nuclear shell.

Eray Enustun
Amar Deep
Kevin D. Corbett
ResearchOpen Access04 Sept 2023
Nature Structural & Molecular Biology

Volume: 30, P: 1653-1662
Genomic reconstruction of the SARS-CoV-2 epidemic in England

A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
ResearchOpen Access14 Oct 2021
Nature

Volume: 600, P: 506-511
Viral speciation through subcellular genetic isolation and virogenesis incompatibility

Virus speciation cannot be fully explained by the evolution of different host specificities. Here, Chaikeeratisak et al. identify ways viruses can remain genetically isolated despite co-infecting the same cell, providing insight into how new virus species evolve.

Vorrapon Chaikeeratisak
Erica A. Birkholz
Joe Pogliano
ResearchOpen Access12 Jan 2021
Nature Communications

Volume: 12, P: 1-9
CD98hc is a target for brain delivery of biotherapeutics

New delivery platforms are needed to allow broader application of biotherapeutics for CNS diseases. Here, the authors show enhanced CNS delivery with a transport vehicle engineered to bind CD98hc, a highly expressed target at the blood-brain barrier.

Kylie S. Chew
Robert C. Wells
Mihalis S. Kariolis
ResearchOpen Access19 Aug 2023
Nature Communications

Volume: 14, P: 1-17
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

A genome-wide association study for attention deficit/hyperactivity disorder (ADHD) identifies 12 loci and implicates neurodevelopmental pathways and conserved regions of the genome as being involved in underlying ADHD biology.

Ditte Demontis
Raymond K. Walters
Benjamin M. Neale
Research26 Nov 2018
Nature Genetics

Volume: 51, P: 63-75
Cerebellar circuit computations for predictive motor control

The cerebellum helps ensure the speed and accuracy of movements, but its precise contributions to movement control are unclear. Nguyen and Person here evaluate evidence for and against feedforward motor control by the cerebellum in light of its well-defined role in a model of associative learning, and reconcile this with theories of internal model-based control.

Katrina P. Nguyen
Abigail L. Person
Reviews16 Jun 2025
Nature Reviews Neuroscience

Volume: 26, P: 538-553
Human pancreatic microenvironment promotes β-cell differentiation via non-canonical WNT5A/JNK and BMP signaling

In vitro differentiation of pancreatic beta cells offers a potential therapeutic approach for diabetes. Here they show human pluripotent stem cell derived pancreatic progenitors differentiate into insulin-secreting cells by crosstalk of WNT5A and BMP signaling.

Jolanta Chmielowiec
Wojciech J. Szlachcic
Malgorzata Borowiak
ResearchOpen Access12 Apr 2022
Nature Communications

Volume: 13, P: 1-18
Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

Progressive diseases tend to be heterogeneous in their underlying aetiology mechanism, disease manifestation, and disease time course. Here, Young and colleagues devise a computational method to account for both phenotypic heterogeneity and temporal heterogeneity, and demonstrate it using two neurodegenerative disease cohorts.

Alexandra L Young
Razvan V Marinescu
Ansgar J Furst
ResearchOpen Access15 Oct 2018
Nature Communications

Volume: 9, P: 1-16
An integrated encyclopedia of DNA elements in the human genome

This overview of the ENCODE project outlines the data accumulated so far, revealing that 80% of the human genome now has at least one biochemical function assigned to it; the newly identified functional elements should aid the interpretation of results of genome-wide association studies, as many correspond to sites of association with human disease.

Ian Dunham
Anshul Kundaje
Ewan Birney
ResearchOpen Access05 Sept 2012
Nature

Volume: 489, P: 57-74
Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

A randomized trial in patients hospitalized with COVID-19 showed no benefit and potentially increased harm associated with the use of convalescent plasma, with subgroup analyses suggesting that the antibody profile in donor plasma is critical in determining clinical outcomes.

Philippe Bégin
Jeannie Callum
Donald M. Arnold
ResearchOpen Access09 Sept 2021
Nature Medicine

Volume: 27, P: 2012-2024
Author Correction: CD98hc is a target for brain delivery of biotherapeutics

Kylie S. Chew
Robert C. Wells
Mihalis S. Kariolis
Amendments and CorrectionsOpen Access07 Sept 2023
Nature Communications

Volume: 14, P: 1
Analysis of changes in intercellular communications in Alzheimer’s disease reveals conserved changes in glutamatergic transmission in mice and humans

Katrina Bartas
Megan Nguyen
Kevin T. Beier
ResearchOpen Access19 Jul 2025
Scientific Reports

Volume: 15, P: 1-22
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

GNPS is an open-access community-curated analysis platform for sharing natural product mass spectrometry data that enables continuous, automatic reanalysis of deposited 'living' data sets.

Mingxun Wang
Jeremy J Carver
Nuno Bandeira
Reviews09 Aug 2016
Nature Biotechnology

Volume: 34, P: 828-837
Targeting miR-126 in Ph+ acute lymphoblastic leukemia

Junjing Qiao
Dandan Zhao
Bin Zhang
ResearchOpen Access09 Jun 2023
Leukemia

Volume: 37, P: 1540-1544
Arrhythmogenic and antiarrhythmic actions of late sustained sodium current in the adult human heart

Anh Tuan Ton
William Nguyen
Najah Abi-Gerges
ResearchOpen Access08 Jun 2021
Scientific Reports

Volume: 11, P: 1-16
The Somatic Mosaicism across Human Tissues Network

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Tim H. H. Coorens
Ji Won Oh
Yuqing Wang
Reviews02 Jul 2025
Nature

Volume: 643, P: 47-59
Resetting the histone code at CDKN2A in HNSCC by inhibition of DNA methylation

Madelene M Coombes
Katrina L Briggs
Sharon YR Dent
Research04 Dec 2003
Oncogene

Volume: 22, P: 8902-8911
OST-01, a natural product from Baccharis coridifolia, targets c-Myc-dependent ribogenesis in acute myeloid leukemia

HyunJun Kang
Dinh Hoa Hoang
Guido Marcucci
ResearchOpen Access17 Jan 2024
Leukemia

Volume: 38, P: 657-662
Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis

Ma, Hernandez et al develop a 3D culture-transplant system to enable studies of cancer metastasis using patient-derived xenograft (PDX) tumor cells. Using this system, they find that OXPHOS inhibition attenuates the lung metastatic capacity of breast cancer cells and that overexpression of the metabolic enzyme NME1 increases lung metastasis.

Dennis Ma
Grace A. Hernandez
Devon A. Lawson
ResearchOpen Access05 Nov 2021
Communications Biology

Volume: 4, P: 1-15
Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
Amendments and CorrectionsOpen Access07 Jun 2022
Nature

Volume: 606, P: E18
A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells

Katrina M Bockbrader
Mingjia Tan
Yi Sun
Research25 Jul 2005
Oncogene

Volume: 24, P: 7381-7388
Striatopallidal neurons control avoidance behavior in exploratory tasks

Kimberly H. LeBlanc
Tanisha D. London
Alexxai V. Kravitz
ResearchOpen Access25 Apr 2018
Molecular Psychiatry

Volume: 25, P: 491-505
Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Research10 Jan 2022
Nature Medicine

Volume: 28, P: 53-58
Hypoxic human proximal tubular epithelial cells undergo ferroptosis and elicit an NLRP3 inflammasome response in CD1c⁺ dendritic cells

Kurt T. K. Giuliani
Anca Grivei
Andrew J. Kassianos
ResearchOpen Access27 Aug 2022
Cell Death & Disease

Volume: 13, P: 1-13
T cell signaling and Treg dysfunction correlate to disease kinetics in IL-2Rα-KO autoimmune mice

Genevieve N. Mullins
Kristen M. Valentine
Katrina K. Hoyer
ResearchOpen Access15 Dec 2020
Scientific Reports

Volume: 10, P: 1-16
Correction: Striatopallidal neurons control avoidance behavior in exploratory tasks

Kimberly H. LeBlanc
Tanisha D. London
Alexxai V. Kravitz
Amendments and CorrectionsOpen Access31 Jul 2019
Molecular Psychiatry

Volume: 25, P: 506
Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Amendments and CorrectionsOpen Access12 Jan 2022
Nature Medicine

Volume: 28, P: 212
Bi-allelic ATG4D variants are associated with a neurodevelopmental disorder characterized by speech and motor impairment

Marie Morimoto
Vikas Bhambhani
May Christine V. Malicdan
ResearchOpen Access10 Feb 2023
npj Genomic Medicine

Volume: 8, P: 1-16
Microfluidic channel optimization to improve hydrodynamic dissociation of cell aggregates and tissue

Xiaolong Qiu
Jen-Huang Huang
Jered B. Haun
ResearchOpen Access09 Feb 2018
Scientific Reports

Volume: 8, P: 1-10

Search

Recurrent pattern completion drives the neocortical representation of sensory inference

miR-142 deficit in T cells during blast crisis promotes chronic myeloid leukemia immune escape

Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis

Detection of co-infection and recombination cases with Omicron and local Delta variants of SARS-CoV-2 in Vietnam

Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes

Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia

Comparison of AI-integrated pathways with human-AI interaction in population mammographic screening for breast cancer

IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern

Identification of the bacteriophage nucleus protein interaction network

Genomic reconstruction of the SARS-CoV-2 epidemic in England

Viral speciation through subcellular genetic isolation and virogenesis incompatibility

CD98hc is a target for brain delivery of biotherapeutics

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

Cerebellar circuit computations for predictive motor control

Human pancreatic microenvironment promotes β-cell differentiation via non-canonical WNT5A/JNK and BMP signaling

Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

An integrated encyclopedia of DNA elements in the human genome

Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Author Correction: CD98hc is a target for brain delivery of biotherapeutics

Analysis of changes in intercellular communications in Alzheimer’s disease reveals conserved changes in glutamatergic transmission in mice and humans

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

Targeting miR-126 in Ph+ acute lymphoblastic leukemia

Arrhythmogenic and antiarrhythmic actions of late sustained sodium current in the adult human heart

The Somatic Mosaicism across Human Tissues Network

Resetting the histone code at CDKN2A in HNSCC by inhibition of DNA methylation

OST-01, a natural product from Baccharis coridifolia, targets c-Myc-dependent ribogenesis in acute myeloid leukemia

Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis

Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England

A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells

Striatopallidal neurons control avoidance behavior in exploratory tasks

Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Hypoxic human proximal tubular epithelial cells undergo ferroptosis and elicit an NLRP3 inflammasome response in CD1c⁺ dendritic cells

T cell signaling and Treg dysfunction correlate to disease kinetics in IL-2Rα-KO autoimmune mice

Correction: Striatopallidal neurons control avoidance behavior in exploratory tasks

Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Bi-allelic ATG4D variants are associated with a neurodevelopmental disorder characterized by speech and motor impairment

Microfluidic channel optimization to improve hydrodynamic dissociation of cell aggregates and tissue

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