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Showing 1–15 of 15 results
Advanced filters: Author: Kay Diederichs Clear advanced filters

  • The study identifies two antibiotic efflux pump clusters with distinct conserved residues affecting antibiotic resistance by altering conformations and substrate binding. Cryo-EM reveals pump apo states, indicating diverse substrate binding mechanisms linked to resistance.

    • Mariya Lazarova
    • Thomas Eicher
    • Klaas M. Pos
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Many efforts to expand the genetic alphabet and reprogram the genetic code have relied on synthetic DNA nucleotides designed to have pairing properties orthogonal to those of natural base pairs. A structural study shows that DNA polymerases enhance the efficiency of non-natural base pair replication by enforcing a standard Watson-Crick geometry in the polymerase active site.

    • Karin Betz
    • Denis A Malyshev
    • Andreas Marx
    Research
    Nature Chemical Biology
    Volume: 8, P: 612-614

  • The validation and analysis of X-ray crystallographic data is essential for reproducibility and the development of crystallographic methods. Here, the authors describe a repository for crystallographic datasets and demonstrate some of the ways it could serve the crystallographic community.

    • Peter A. Meyer
    • Stephanie Socias
    • Piotr Sliz
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • RNA ligases are present across all forms of life. Here, the hitherto uncharacterised human protein C12orf29 was identified as a human enzyme promoting RNA ligation between 5′-PO4 and 3′-OH termini. This data provides the groundwork for establishing a human RNA repair pathway.

    • Yizhi Yuan
    • Florian M. Stumpf
    • Andreas Marx
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • Diacylglycerol kinase is a small bacterial membrane-bound trimer that catalyses diacylglycerol conversion to phosphatidic acid. Here, the authors solve the crystal structure of the kinase bound to a lipid substrate and an ATP analogue, and show that the active site arose through convergent evolution.

    • Dianfan Li
    • Phillip J. Stansfeld
    • Martin Caffrey
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-12

  • Here the structure of the membrane protein complex sodium-translocating NADH:quinone oxidoreductase (Na+-NQR) is described; as Na+-NQR is a component of the respiratory chain of various bacteria, including pathogenic ones, this structure may serve as the basis for the development of new antibiotics.

    • Julia Steuber
    • Georg Vohl
    • Günter Fritz
    Research
    Nature
    Volume: 516, P: 62-67

  • G protein-coupled receptors are a large family of signalling proteins that mediate cellular responses primarily via G proteins or arrestins, and they are targets of one-third of the current clinically used drugs; here, an active form of human rhodopsin bound to a pre-activated form of the mouse visual arrestin-1 is determined, revealing unique structural features that may constitute essential elements for arrestin-biased signalling.

    • Yanyong Kang
    • X. Edward Zhou
    • H. Eric Xu
    Research
    Nature
    Volume: 523, P: 561-567

  • This Primer offers a practical and rational introduction to macromolecular crystallography, whether to engage directly with or to critically assess results, with a focus on understanding the diffraction data, solving the phase problem, building and refining the atomic model, and interpreting the resulting atomic structure.

    • Pavel V. Afonine
    • Armando Albert
    • Isabel Usón
    Reviews
    Nature Reviews Methods Primers
    Volume: 5, P: 1-25

  • Structural biology plays a crucial role in the fight against COVID-19, permitting us to ‘see’ and understand SARS-CoV-2. However, the macromolecular structures of SARS-CoV-2 proteins that were solved with great speed and urgency can contain errors that may hinder drug design. The Coronavirus Structural Task Force has been working behind the scenes to evaluate and improve these structures, making the results freely available at https://insidecorona.net/.

    • Tristan I. Croll
    • Kay Diederichs
    • Andrea Thorn
    Comments & Opinion
    Nature Structural & Molecular Biology
    Volume: 28, P: 404-408

  • Huang et al. report a fully automated method for collecting and merging data from thousands of in meso-grown microcrystals. This in situ approach provides a fast and efficient way to determine the structures of membrane proteins from fragile microcrystals.

    • Chia-Ying Huang
    • Vincent Olieric
    • Meitian Wang
    ResearchOpen Access
    Communications Biology
    Volume: 1, P: 1-8