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Showing 1–4 of 4 results

Advanced filters: Author: Kazuharu Hanada Clear advanced filters

CXCR4 induces memory formation over exhaustion in CAR-T cells to achieve durable leukemia targeting

CAR-T cell efficacy is often limited by the inability to maintain a memory T cell program. Here, the authors show that intrinsic CXCR4 expression enhances CAR-T cell persistence and memory differentiation in acute myeloid leukemia.

Ari Itoh-Nakadai
Minggao Liang
Fumihiko Ishikawa
ResearchOpen Access26 Jan 2026
Nature Communications

Volume: 17, P: 1-21
Carotenoids bind rhodopsins and act as photocycle-accelerating pigments in marine Bacteroidota

In marine bacteria, carotenoids enhance rhodopsin function by acting as light-harvesting antennae and photocycle-accelerating pigments, a dual mechanism that enhances light energy capture and expands the known strategies of microbial phototrophy.

Takayoshi Fujiwara
Toshiaki Hosaka
Susumu Yoshizawa
Research04 Sept 2025
Nature Microbiology

Volume: 10, P: 2603-2615
Conformational alteration of DOCK5•ELMO1 signalosome on lipid membrane

Membrane-flattened DOCK5–ELMO1–RhoG–Rac1 complexes reveal that conformational changes from hinge rotations and ELMO1 PH domain–lipid interactions cooperatively regulate DOCK5 GEF activity and downstream signalling.

Takehiro Shinoda
Kazushige Katsura
Mikako Shirouzu
ResearchOpen Access13 Nov 2025
Communications Biology

Volume: 8, P: 1-10
Targeting Ras-binding domain of ELMO1 by computational nanobody design

Structural analysis of the Ras-binding domain (RBD) of ELMO1 alone and in complex with the activator RhoG enables rational engineering and validation of a nanobody targeting ELMO1 RBD.

Chunlai Tam
Mutsuko Kukimoto-Niino
Kam Y. J. Zhang
ResearchOpen Access17 Mar 2023
Communications Biology

Volume: 6, P: 1-11