Nature Search

DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

Here, Imamuraet al. conduct meta-analysis of genome-wide association studies to identify novel susceptibility loci for type 2 diabetes (T2D) in the Japanese population. By doing so, this study shows that both ethnicity-specific and ethnically-shared genetic loci can contribute to T2D risk.

Minako Imamura
Atsushi Takahashi
Takashi Kadowaki
ResearchOpen Access28 Jan 2016
Nature Communications

Volume: 7, P: 1-12
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
High-frequency ultrasound for microcirculation in metastatic mouse lymph node: contrast-free versus contrast-enhanced imaging

Kazuki Maeda
Masaaki Omura
Tetsuya Kodama
ResearchOpen Access05 Dec 2025
Scientific Reports

Volume: 15, P: 1-12
The validity and reliability of a Japanese version of the web-based hamstring outcome score

Shogo Tsutsumi
Noriaki Maeda
Yukio Urabe
ResearchOpen Access14 Oct 2024
Scientific Reports

Volume: 14, P: 1-8
Identification of the FSH-RH as the other gonadotropin-releasing hormone

Folliculogenesis and ovulation are regulated by separate hormones (FSH and LH), though the release of both has been thought to be regulated by the same upstream hormone, GnRH. Here they show that in fish, FSH release is regulated by a distinct hormone, FSH-RH, thereby revisiting our current understanding of gonadotropin release.

Shun Kenny Uehara
Yuji Nishiike
Shinji Kanda
ResearchOpen Access27 Jun 2024
Nature Communications

Volume: 15, P: 1-15
Selective-plane-activation structured illumination microscopy

The combination of light sheet illumination and reversibly switchable fluorophores enables improved structured illumination microscopy for fast, low-background super-resolution imaging in cells and spheroids.

Kenta Temma
Ryosuke Oketani
Katsumasa Fujita
Research05 Apr 2024
Nature Methods

Volume: 21, P: 889-896
The effect of arterial spin labeling MR angiography (ASL-MRA) in visualizing the branches of external carotid artery

Akira Yogi
Junji Ito
Akihiro Nishie
ResearchOpen Access24 Feb 2024
Scientific Reports

Volume: 14, P: 1-10
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Higher abundance of Campylobacter in the oral microbiome of Japanese patients with moyamoya disease

Kai Takayanagi
Fumiaki Kanamori
Ryuta Saito
ResearchOpen Access29 Oct 2023
Scientific Reports

Volume: 13, P: 1-8
Transthyretin amyloid deposition in ligamentum flavum (LF) is significantly correlated with LF and epidural fat hypertrophy in patients with lumbar spinal stenosis

Kazuya Maeda
Kazuki Sugimoto
Takeshi Miyamoto
ResearchOpen Access16 Nov 2023
Scientific Reports

Volume: 13, P: 1-8
The relationship between traction spurs, Modic change, vacuum phenomenon, and segmental instability of the lumbar spine

Masatsugu Tsukamoto
Tadatsugu Morimoto
Masaaki Mawatari
ResearchOpen Access15 Jun 2022
Scientific Reports

Volume: 12, P: 1-8
Quantitative evaluation of the vertical mobility of the first tarsometatarsal joint during stance phase of gait

Noriaki Maeda
Yasunari Ikuta
Yukio Urabe
ResearchOpen Access02 Jun 2022
Scientific Reports

Volume: 12, P: 1-7
Differential brain volume between obese and underweight cognitively normal older adults with frailty in the JPSC-AD

Naoki Ishizuka
Hiroshi Akasaka
Yutaka Kiyohara
ResearchOpen Access04 Jun 2025
Scientific Reports

Volume: 15, P: 1-12
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Hyperbranched Polymer through Initiator-Fragment Incorporation Radical Copolymerization of Divinyl Adipate with Allyl Acetate: Synthesis, Characterization, Dye Solubilization, Metal-Nanoparticle Stabilization, and Porous Film Formation

Tsuneyuki Sato
Kazuki Nomura
Makiko Seno
Reviews15 Feb 2006
Polymer Journal

Volume: 38, P: 240-249
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus

Masato Kasuga and colleagues and Shiro Maeda and colleagues each report the independent identification of SNPs in KCNQ1 associated with type 2 diabetes in the Japanese population. Each group replicated the associations in other populations of East Asian and European descent.

Kazuki Yasuda
Kazuaki Miyake
Masato Kasuga
Research17 Aug 2008
Nature Genetics

Volume: 40, P: 1092-1097
K-Ras is essential for the development of the mouse embryo

Keiko Koera
Kenji Nakamura
Motoya Katsuki
Research04 Sept 1997
Oncogene

Volume: 15, P: 1151-1159
Intensive or standard blood pressure control in patients with a history of ischemic stroke: RESPECT post hoc analysis

A total of 1074 patients with a history of ischemic stroke enrolled in The Recurrent Stroke Prevention Clinical Outcome (RESPECT) Study were assigned to intensive blood pressure (BP) control group (blood pressure < 120/80 mmHg) or standard blood pressure control group (blood pressure < 140/90 mmHg) and were followed up for a mean of 3.9 years. Seventy-eight first recurrent strokes occurred, including 70 ischemic stroke and 8 intracerebral hemorrhage. Intensive treatment did not change annual risk of ischemic stroke (1.74% vs. 1.75%, P = 0.999), but markedly reduced risk of hemorrhagic stroke (0.00% vs. 0.39%, P = 0.005). Beneficial effect of intensive BP control were observed for risk of hemorrhagic stroke in the patients with a history of ischemic stroke.

Kazuo Kitagawa
Hisatomi Arima
Seigo Nakada
Research04 Mar 2022
Hypertension Research

Volume: 45, P: 591-601
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

Toshimasa Yamauchi and colleagues report results of a genome-wide association study of type 2 diabetes in the Japanese population. They identify new risk loci at UBE2E2 and C2CD4A-C2CD4B and show that the latter is also associated with type 2 diabetes risk in Europeans.

Toshimasa Yamauchi
Kazuo Hara
Takashi Kadowaki
Research05 Sept 2010
Nature Genetics

Volume: 42, P: 864-868
Author Correction: Structure and function of a β-1,2-galactosidase from Bacteroides xylanisolvens, an intestinal bacterium

Yutaka Nakazawa
Masumi Kageyama
Masahiro Nakajima
Amendments and CorrectionsOpen Access07 Feb 2025
Communications Biology

Volume: 8, P: 1
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Overcoming thermostability challenges in mRNA–lipid nanoparticle systems with piperidine-based ionizable lipids

Piperidine-based ionizable lipids avoid the formation of mRNA–lipid adduct that is responsible for the loss-of-function of mRNA and contribute to the long-term storage stability of mRNA/LNPs as a wet preparation.

Kazuki Hashiba
Masamitsu Taguchi
Yusuke Sato
ResearchOpen Access10 May 2024
Communications Biology

Volume: 7, P: 1-13
A panel of nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants including Omicron

A panel of nanobodies are presented that can detect the spike proteins of five SARS-CoV-2 variants of concern and structural analyses show that one clone targets conserved epitopes on the receptor-binding domain and contacts the N-terminal domain.

Ryota Maeda
Junso Fujita
Akifumi Takaori-Kondo
ResearchOpen Access06 Jul 2022
Communications Biology

Volume: 5, P: 1-16
Plates made from magnesium alloy with a long period stacking ordered structure promote bone formation in a rabbit fracture model

Kosei Takata
Masaki Yugami
Takeshi Miyamoto
ResearchOpen Access10 Apr 2025
Scientific Reports

Volume: 15, P: 1-9
Notch Signaling Mediates Astrocyte Abnormality in Spinal Muscular Atrophy Model Systems

Kazuki Ohuchi
Michinori Funato
Hideaki Hara
ResearchOpen Access06 Mar 2019
Scientific Reports

Volume: 9, P: 1-14
Structure and function of a β-1,2-galactosidase from Bacteroides xylanisolvens, an intestinal bacterium

A β-galactosidase acting specifically on β-1,2-galactooligosaccharides was found from an intestinal bacterium.

Yutaka Nakazawa
Masumi Kageyama
Masahiro Nakajima
ResearchOpen Access16 Jan 2025
Communications Biology

Volume: 8, P: 1-12
Total hydrocortisone dosage in extremely low birth weight infants and neurodevelopment up to school age

Akinobu Taniguchi
Basile Chrétien
Yoshiaki Sato
ResearchOpen Access23 Sept 2025
Pediatric Research

P: 1-7
Compound heterozygous variants in the ABCG8 gene in a Japanese girl with sitosterolemia

Nobuhiro Hashimoto
Sumito Dateki
Kazuki Yamazawa
ResearchOpen Access14 Sept 2020
Human Genome Variation

Volume: 7, P: 1-4
Thermocompression bonding of conductive polymers for electrical connections in organic electronics

The thermocompression bonding of conductive polymer films was investigated to achieve a flexible wiring and packaging technique for flexible electronics. Conductive polymer poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) films were successfully bonded together by thermocompression, especially through surface activation treatment using ultraviolet light irradiation. After thermocompression, the PEDOT:PSS films maintained their ohmic electrical conductivity even through the adhered interface. The surface state analysis of the PEDOT:PSS indicated that the oxidized species were generated after the surface activation process. These chemical species can interact each other and provide robust bonding interfaces.

Kazuki Maeda
Masashi Nitani
Mayumi Uno
Research18 Dec 2019
Polymer Journal

Volume: 52, P: 405-412
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
The IL-17-IL-17RA axis is required to promote osteosarcoma progression in mice

Naoto Yoshimura
Ryusho Kariya
Takeshi Miyamoto
ResearchOpen Access07 Dec 2023
Scientific Reports

Volume: 13, P: 1-13
Macrophages play a leading role in determining the direction of astrocytic migration in spinal cord injury via ADP-P2Y1R axis

Gentaro Ono
Kazu Kobayakawa
Yasuharu Nakashima
ResearchOpen Access10 Jul 2023
Scientific Reports

Volume: 13, P: 1-12
Genetic Spectrum of EYS-associated Retinal Disease in a Large Japanese Cohort: Identification of Disease-associated Variants with Relatively High Allele Frequency

Lizhu Yang
Kaoru Fujinami
Yasuhiro Murakawa
ResearchOpen Access26 Mar 2020
Scientific Reports

Volume: 10, P: 1-10
Zinc chelator treatment in crush syndrome model mice attenuates ischemia–reperfusion-induced muscle injury due to suppressing of neutrophil infiltration

Yohei Haruta
Kazu Kobayakawa
Yasuharu Nakashima
ResearchOpen Access16 Sept 2022
Scientific Reports

Volume: 12, P: 1-12
Circulating microRNA-214 and -126 as potential biomarkers for canine neoplastic disease

Kazuki Heishima
Yukie Ichikawa
Takashi Mori
ResearchOpen Access23 May 2017
Scientific Reports

Volume: 7, P: 1-14
Live imaging of H3K9 acetylation in plant cells

Kazuki Kurita
Takuya Sakamoto
Sachihiro Matsunaga
ResearchOpen Access18 Apr 2017
Scientific Reports

Volume: 7, P: 1-9
Using linkage logic theory to control dynamics of a gene regulatory network of a chordate embryo

Kenji Kobayashi
Kazuki Maeda
Yutaka Satou
ResearchOpen Access17 Feb 2021
Scientific Reports

Volume: 11, P: 1-11
Light-induced enhancement of superconductivity in iron-based superconductor FeSe_0.5Te_0.5

Light-matter interaction is not only used to melt electronic orders, but also carry the potential as a non-thermal tuning knob to enhance emergent orders. Here the authors demonstrate a light-induced transient enhancement of superconductivity in an iron chalcogenide superconductor via terahertz optical conductivity and terahertz third-harmonic generation by the injection of photo-carriers.

Kazuki Isoyama
Naotaka Yoshikawa
Ryo Shimano
ResearchOpen Access14 Jul 2021
Communications Physics

Volume: 4, P: 1-9
Hyperactivation of mTORC1 disrupts cellular homeostasis in cerebellar Purkinje cells

Yusuke Sakai
Hidetoshi Kassai
Atsu Aiba
ResearchOpen Access26 Feb 2019
Scientific Reports

Volume: 9, P: 1-14
Clinical and Genetic Characteristics of 18 Patients from 13 Japanese Families with CRX-associated retinal disorder: Identification of Genotype-phenotype Association

Yu Fujinami-Yokokawa
Kaoru Fujinami
Yasuhiro Murakawa
ResearchOpen Access12 Jun 2020
Scientific Reports

Volume: 10, P: 1-13
Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association

Kazuaki Miyake
Woosung Yang
Masato Kasuga
Research27 Feb 2009
Journal of Human Genetics

Volume: 54, P: 236-241

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