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Showing 1–10 of 10 results
Advanced filters: Author: Keary M. Engle Clear advanced filters

  • Molecular glue degraders have consistently been discovered retrospectively, despite their increasing importance. Herein, a high-throughput approach is described that modifies existing ligands into molecular glue degraders.

    • James B. Shaum
    • Miquel Muñoz i Ordoño
    • Michael A. Erb
    ResearchOpen Access
    Nature Chemical Biology
    P: 1-13

  • The ambiphilic reactivity of alkyl sulfonyl fluorides in stereoselective cyclopropanation under Pd(II) catalysis is reported. The method provides convenient access to cis-disubstituted cyclopropanes that are otherwise challenging to access. A representative carboxylic acid cyclopropane building block is scaled up to 100 mmol, demonstrating the practicality of this transformation.

    • Yilin Cao
    • Warabhorn Rodphon
    • Keary M. Engle
    ResearchOpen Access
    Nature Synthesis
    Volume: 5, P: 281-289

  • Dihydrobenzofurans and indolines are common substructures in medicines and natural products. Herein, the authors report a palladium-catalyzed [3 + 2] (hetero)annulation proceeding in an anti-selective fashion and enabling direct access to these valuable heterocycles with broad reaction scope.

    • Hui-Qi Ni
    • Ilia Kevlishvili
    • Keary M. Engle
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8

  • Conventional palladium-catalyzed Heck reactions rely on the addition of oxidants and may suffer from low selectivity. Here, the authors report a nickel-catalyzed oxidative Heck arylation driven by transfer hydrogenation of an acceptor olefin leading to high E/Z selectivity and regioselectivity.

    • Honggui Lv
    • Huiying Kang
    • Dongbing Zhao
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • If organic molecules were trees, then the numerous carbon–hydrogen bonds within them would be leaves. A catalyst that targets one 'leaf' out of many similar other ones looks set to be a huge leap for synthetic chemistry. See Letter p.230

    • Kin S. Yang
    • Keary M. Engle
    News & Views
    Nature
    Volume: 533, P: 183-184

  • The synthesis of polymers with diverse properties is often limited by the lack of methods to produce the required monomers. Now, the regio- and diastereoselective synthesis of 5,6-diaryl cyclooctene monomers is reported using nickel catalysis. The monomers can be used in ring-opening metathesis polymerization reactions to form polymers with head-to-head styrene dyads.

    • Van T. Tran
    • Anne K. Ravn
    • Keary M. Engle
    Research
    Nature Synthesis
    Volume: 3, P: 1369-1376

  • Traditionally, strong-bond activation by transition metals has been achieved through an oxidative addition pathway. Now, a redox-neutral palladium(ii)-catalysed β-elimination strategy has been shown to activate alkyl C–O, N, C, F and S bonds to give an alkene that can be trapped with various nucleophiles. This functional group metathesis allows upgrading of amino acid derivatives and ring-opening of saturated heterocycles.

    • Van T. Tran
    • John A. Gurak Jr
    • Keary M. Engle
    Research
    Nature Chemistry
    Volume: 10, P: 1126-1133

  • The regioselectivity of tandem isomerization/hydrocarbonylation reactions is typically dictated by thermodynamics and there are limitations on the isomerization of internal alkenes. Now, it has been shown that a low-valent-tungsten catalyst controls the isomerization of alkenes to classically challenging unactivated internal positions and, with the aid of a directing group, enables subsequent addition of hydrogen and carbon monoxide.

    • Tanner C. Jankins
    • William C. Bell
    • Keary M. Engle
    Research
    Nature Chemistry
    Volume: 14, P: 632-639