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Showing 1–6 of 6 results

Advanced filters: Author: Kedar Sharma Clear advanced filters

Molecular basis of the urate transporter URAT1 inhibition by gout drugs

URAT1 is the target for gout drugs that block urate reuptake in the kidneys, however current treatments have limitations. Here, authors show how urate-lowering drugs inhibit URAT1, facilitating antigout drug development.

Yang Suo
Justin G. Fedor
Seok-Yong Lee
ResearchOpen Access04 Jun 2025
Nature Communications

Volume: 16, P: 1-13
Molecular basis of neurosteroid and anticonvulsant regulation of TRPM3

The authors present cryo-electron microscopy structures of the TRPM3 channel and provide insights into neurosteroid and synthetic agonist recognition and activation, anticonvulsant inhibition and the effects of disease mutations on channel gating.

Ying Yin
Cheon-Gyu Park
Seok-Yong Lee
Research14 Jan 2025
Nature Structural & Molecular Biology

Volume: 32, P: 828-840
Metastable 1T′-phase group VIB transition metal dichalcogenide crystals

A general method for the synthesis of high-purity crystals of metastable 1T′-phase transition metal dichalcogenides is reported, providing a source of phase-engineered materials that can be used to systematically explore their intrinsic properties.

Zhuangchai Lai
Qiyuan He
Hua Zhang
Research15 Apr 2021
Nature Materials

Volume: 20, P: 1113-1120
Antiviral drug recognition and elevator-type transport motions of CNT3

Structural, functional and computational studies uncover the molecular details of antiviral drug recognition and membrane translocation by a concentrative nucleoside transporter.

Nicholas J. Wright
Feng Zhang
Seok-Yong Lee
Research28 Feb 2024
Nature Chemical Biology

Volume: 20, P: 1144-1153
Expression of pancreatic α-amylase and growth related genes during larval ontogeny in striped murrel (Channa striata)

Rakhi Kumari
P. P. Srivastava
G. M. Siddaiah
ResearchOpen Access30 Sept 2025
Scientific Reports

Volume: 15, P: 1-17
Reproducibility of spatial penalty-based methodologies for intravoxel incoherent motion analysis with diffusion MRI

Esha Baidya Kayal
Shuvadeep Ganguly
Amit Mehndiratta
ResearchOpen Access01 Oct 2024
Scientific Reports

Volume: 14, P: 1-16