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Sequential lymphotoxin-β receptor and retinoic acid receptor signals regulate cDC2 fate

Nguyen et al. show that the splenic environment provides sequential signals via lymphotoxin and retinoic acid that guide cDC2A development and retention.

Albert A. Nguyen
Logan Fisher
Chrysothemis C. Brown
Research21 Nov 2025
Nature Immunology

Volume: 26, P: 2159-2169
IL-9 receptor signaling in memory B cells regulates humoral recall responses

Signaling via the cytokine IL-9 receptor regulates humoral recall responses. Kitamura and colleagues report that IL-9 triggers memory B cells to proliferate and terminally differentiate into antibody-secreting cells rather than re-entering germinal centers.

Shogo Takatsuka
Hiroyuki Yamada
Daisuke Kitamura
Research06 Aug 2018
Nature Immunology

Volume: 19, P: 1025-1034
In-vitro derived germinal centre B cells differentially generate memory B or plasma cells in vivo

In response to antigens, B cells proliferate and form germinal centres before differentiating into memory B cells or long-lived plasma cells. Here, a culture method is used to expand B cells in vitro, with the ability to shift the fate of the cells between memory B cells and long-lived plasma cells.

Takuya Nojima
Kei Haniuda
Daisuke Kitamura
Research06 Sept 2011
Nature Communications

Volume: 2, P: 1-11
Autonomous membrane IgE signaling prevents IgE-memory formation

Under normal conditions, IgE⁺ memory B cells and IgE serum antibody are extremely scarce. Kitamura and colleagues demonstrate that the IgE B cell receptor has unique signaling properties that autonomously control IgE⁺ B cell numbers.

Kei Haniuda
Saori Fukao
Daisuke Kitamura
Research18 Jul 2016
Nature Immunology

Volume: 17, P: 1109-1117
Neonatal LTβR signaling is required for the accumulation of eosinophils in the inflamed adult mesenteric lymph node

Conglei Li
Lesley A. Ward
Jennifer L. Gommerman
Research18 Feb 2022
Mucosal Immunology

Volume: 15, P: 418-427

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Sequential lymphotoxin-β receptor and retinoic acid receptor signals regulate cDC2 fate

IL-9 receptor signaling in memory B cells regulates humoral recall responses

In-vitro derived germinal centre B cells differentially generate memory B or plasma cells in vivo

Autonomous membrane IgE signaling prevents IgE-memory formation

Neonatal LTβR signaling is required for the accumulation of eosinophils in the inflamed adult mesenteric lymph node

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