Rab8 is a small GTP-binding protein thought to regulate basolateral transport in vitro. In this paper, Rab8 conditional knockout mice are used to show that Rab8 plays an important part in vivo in the maintenance of the apical surface of intestinal cells; the mice eventually starve owing to poor absorption of food.
- Takashi Sato
- Sotaro Mushiake
- Akihiro Harada
