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Structural dynamics of mixed-subunit CaMKIIα/β heterododecamers filmed by high-speed AFM

High-speed AFM reveals CaMKIIα/β subunits are mixed within 12-unit rings, with βs frequently neighboring. Activated heterooligomers form stable kinase complexes, shedding light on their structural function in neuroplasticity.

Keisuke Matsushima
Takashi Sumikama
Mikihiro Shibata
ResearchOpen Access24 Dec 2025
Nature Communications

Volume: 16, P: 1-14
Editorial Expression of Concern: Living annulative π-extension polymerization for graphene nanoribbon synthesis

Yuuta Yano
Nobuhiko Mitoma
Kenichiro Itami
Amendments and Corrections18 Sept 2020
Nature

Volume: 586, P: E13
Retraction Note: Living annulative π-extension polymerization for graphene nanoribbon synthesis

Yuuta Yano
Nobuhiko Mitoma
Kenichiro Itami
Amendments and Corrections25 Nov 2020
Nature

Volume: 588, P: 180
BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities

Nicotinamide riboside (NR) is a NAD + precursor exhibiting beneficial effects against aging. Here the authors demonstrate that orally administered NR increases NAD + levels in a diphasic manner and that bone marrow stromal cell antigen 1 plays a crucial role for NAD + synthesis from NR.

Keisuke Yaku
Sailesh Palikhe
Takashi Nakagawa
ResearchOpen Access19 Nov 2021
Nature Communications

Volume: 12, P: 1-17
Establishment of a HFpEF model using female Dahl salt-sensitive rats: a valuable tool for elucidating the pathophysiology of HFpEF in women

Hiroka Nakashima
Keisuke Shinohara
Kohtaro Abe
Research28 Nov 2024
Hypertension Research

Volume: 48, P: 672-680
Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin

Hair is a skin component that functions as a physical barrier and thermal regulator. Nagao and colleagues show that hair follicles recruit Langerhans cells to the epidermis via the secretion of various chemokines.

Keisuke Nagao
Tetsuro Kobayashi
Masayuki Amagai
Research24 Jun 2012
Nature Immunology

Volume: 13, P: 744-752
Goreisan attenuates cardiac hypertrophy and diastolic dysfunction in heart failure with preserved ejection fraction induced by HFD/L-NAME via regulation of ICAT-β-catenin/ERK axis

Yoko Shojima Isayama
Shouji Matsushima
Kohtaro Abe
ResearchOpen Access03 Sept 2025
Hypertension Research

Volume: 48, P: 2882-2896
Lobar microbleeds are associated with cognitive impairment in patients with lacunar infarction

Masahiro Nakamori
Naohisa Hosomi
Hirofumi Maruyama
ResearchOpen Access02 Oct 2020
Scientific Reports

Volume: 10, P: 1-8
RETRACTED ARTICLE: Living annulative π-extension polymerization for graphene nanoribbon synthesis

A solution-based living annulative π-extension polymerization technique produces graphene nanoribbons with simultaneous control over their length, width and edges, resulting in the synthesis of graphene nanoribbon block copolymers.

Yuuta Yano
Nobuhiko Mitoma
Kenichiro Itami
Research26 Jun 2019
Nature

Volume: 571, P: 387-392
Triglyceride/high density lipoprotein cholesterol index and future cardiovascular events in diabetic patients without known cardiovascular disease

Ryosuke Nakashima
Shota Ikeda
Kohtaro Abe
ResearchOpen Access17 Mar 2025
Scientific Reports

Volume: 15, P: 1-10
Prognostic impact of moderate to severe anemia associated with renal dysfunction in patients with heart failure

Eri Noda
Shouji Matsushima
Kohtaro Abe
ResearchOpen Access31 Jan 2025
Scientific Reports

Volume: 15, P: 1-14
Efficacy of intensive lipid-lowering therapy with statins stratified by blood pressure levels in patients with type 2 diabetes mellitus and retinopathy: Insight from the EMPATHY study

Among type 2 diabetic patients with retinopathy having blood pressure ≥130/80 mmHg, intensive statin therapy targeting LDL-C <70 mg/dL had benefits in primary CVD prevention compared with standard therapy.

Keisuke Shinohara
Shota Ikeda
Hiroyuki Tsutsui
Research15 Sept 2021
Hypertension Research

Volume: 44, P: 1606-1616
Esaxerenone: blood pressure reduction and cardiorenal protection without reflex sympathetic activation in salt-loaded stroke-prone spontaneously hypertensive rats

Esaxerenone has antihypertensive and cardiorenal protective effects without reflex sympathetic activation in salt-loaded stroke-prone spontaneously hypertensive rats.

Shota Ikeda
Keisuke Shinohara
Shintaro Kinugawa
Research27 May 2024
Hypertension Research

Volume: 47, P: 2133-2143
Association of baseline electrocardiographic left ventricular hypertrophy with future renal function decline in the general population

Shota Ikeda
Keisuke Shinohara
Shintaro Kinugawa
ResearchOpen Access03 Jan 2024
Scientific Reports

Volume: 14, P: 1-8
Clinical characteristics and predictive biomarkers of intensive care unit-acquired weakness in patients with cardiogenic shock requiring mechanical circulatory support

Tae Higuchi
Tomomi Ide
Kohtaro Abe
ResearchOpen Access28 Jan 2025
Scientific Reports

Volume: 15, P: 1-10
A higher resting heart rate is associated with cardiovascular event risk in patients with type 2 diabetes mellitus without known cardiovascular disease

High resting heart rate (RHR), particularly ≥70 bpm, was associated with the risk of cardiovascular events compared to RHR 60-69 bpm in patients with type 2 diabetes mellitus (T2DM), diabetic retinopathy, and hyperlipidemia, but without known cardiovascular disease.

Shota Ikeda
Keisuke Shinohara
Hiroyuki Tsutsui
Research27 Jan 2023
Hypertension Research

Volume: 46, P: 1090-1099
Association between food texture levels consumed and the prevalence of malnutrition and sarcopenia in older patients after stroke

Akio Shimizu
Ichiro Fujishima
Naoharu Mori
Research13 Apr 2022
European Journal of Clinical Nutrition

Volume: 76, P: 1576-1582
Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C

Masashi Mizokami and colleagues report a genome-wide association study to hepatitis C treatment response in two Japanese cohorts. They report common variants at IL28B associated with sustained as well as null virologic response following pegylated interferon-alpha and ribavirin combined therapy.

Yasuhito Tanaka
Nao Nishida
Masashi Mizokami
Research13 Sept 2009
Nature Genetics

Volume: 41, P: 1105-1109
Physical performance and maximum tongue pressure associated with oral intake independence: a retrospective study on hospitalized patients with heart failure

Junichi Yokota
Ren Takahashi
Keisuke Matsushima
ResearchOpen Access03 Nov 2022
Scientific Reports

Volume: 12, P: 1-10
Characterization of the expression of LAT1 as a prognostic indicator and a therapeutic target in renal cell carcinoma

Kosuke Higuchi
Shinichi Sakamoto
Naohiko Anzai
ResearchOpen Access20 Nov 2019
Scientific Reports

Volume: 9, P: 1-10
Doxycycline induces apoptosis via ER stress selectively to cells with a cancer stem cell-like properties: importance of stem cell plasticity

Takashi Matsumoto
Takeshi Uchiumi
Dongchon Kang
ResearchOpen Access29 Nov 2017
Oncogenesis

Volume: 6, P: 1-11
Underestimation of renal artery lumen diameter by computed tomography has consequences for the assessment of patient eligibility for renal denervation

Keisuke Okamura
Masatoshi Matsushima
Shin-ichiro Miura
Correspondence17 May 2024
Hypertension Research

Volume: 47, P: 2784-2785
Age-specific assessment of initial hemoglobin levels and shock index for predicting life-saving interventions in pediatric blunt liver and spleen injuries

Tetsuya Yumoto
Takafumi Obara
Tamotsu Gotou
ResearchOpen Access12 Mar 2025
Scientific Reports

Volume: 15, P: 1-10

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Structural dynamics of mixed-subunit CaMKIIα/β heterododecamers filmed by high-speed AFM

Editorial Expression of Concern: Living annulative π-extension polymerization for graphene nanoribbon synthesis

Retraction Note: Living annulative π-extension polymerization for graphene nanoribbon synthesis

BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities

Establishment of a HFpEF model using female Dahl salt-sensitive rats: a valuable tool for elucidating the pathophysiology of HFpEF in women

Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin

Goreisan attenuates cardiac hypertrophy and diastolic dysfunction in heart failure with preserved ejection fraction induced by HFD/L-NAME via regulation of ICAT-β-catenin/ERK axis

Lobar microbleeds are associated with cognitive impairment in patients with lacunar infarction

RETRACTED ARTICLE: Living annulative π-extension polymerization for graphene nanoribbon synthesis

Triglyceride/high density lipoprotein cholesterol index and future cardiovascular events in diabetic patients without known cardiovascular disease

Prognostic impact of moderate to severe anemia associated with renal dysfunction in patients with heart failure

Efficacy of intensive lipid-lowering therapy with statins stratified by blood pressure levels in patients with type 2 diabetes mellitus and retinopathy: Insight from the EMPATHY study

Esaxerenone: blood pressure reduction and cardiorenal protection without reflex sympathetic activation in salt-loaded stroke-prone spontaneously hypertensive rats

Association of baseline electrocardiographic left ventricular hypertrophy with future renal function decline in the general population

Clinical characteristics and predictive biomarkers of intensive care unit-acquired weakness in patients with cardiogenic shock requiring mechanical circulatory support

A higher resting heart rate is associated with cardiovascular event risk in patients with type 2 diabetes mellitus without known cardiovascular disease

Association between food texture levels consumed and the prevalence of malnutrition and sarcopenia in older patients after stroke

Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C

Physical performance and maximum tongue pressure associated with oral intake independence: a retrospective study on hospitalized patients with heart failure

Characterization of the expression of LAT1 as a prognostic indicator and a therapeutic target in renal cell carcinoma

Doxycycline induces apoptosis via ER stress selectively to cells with a cancer stem cell-like properties: importance of stem cell plasticity

Underestimation of renal artery lumen diameter by computed tomography has consequences for the assessment of patient eligibility for renal denervation

Age-specific assessment of initial hemoglobin levels and shock index for predicting life-saving interventions in pediatric blunt liver and spleen injuries

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