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Showing 1–7 of 7 results
Advanced filters: Author: Kelly Del Tredici Clear advanced filters

  • In 1912, Fritz Heinrich Lewy identified the intracellular inclusions that are characteristic of Parkinson disease (PD). Here, Goedert and colleagues present an overview of Lewy's life, including the events leading up to the discovery of the inclusion bodies that now bear his name. They go on to discuss the central role of Lewy pathology in PD and other neurodegenerative disorders, and the research that has elucidated the mechanisms through which α-synuclein aggregation causes neuronal dysfunction and death.

    • Michel Goedert
    • Maria Grazia Spillantini
    • Heiko Braak
    Reviews
    Nature Reviews Neurology
    Volume: 9, P: 13-24

  • Prion-like propagation of pathogenic proteins has been suggested to underlie several neurodegenerative diseases. In this Perspectives article, Braak et al. posit that progressive lesions in amyotrophic lateral sclerosis (ALS) spread through cell-to-cell transfer of 43-kDA transactive response DNA-binding protein, mainly through cortical neuronal projections to other brain areas and the spinal cord. This model could have important implications for our understanding of ALS and approach to treatment.

    • Heiko Braak
    • Johannes Brettschneider
    • Kelly Del Tredici
    Reviews
    Nature Reviews Neurology
    Volume: 9, P: 708-714

  • Three postmortem studies examine long-term fetal transplants in subjects with advanced Parkinson's disease. The findings—such as the development of parkinsonian pathology in some transplanted neurons—underscore the limitations of this approach.

    • Heiko Braak
    • Kelly Del Tredici
    News & Views
    Nature Medicine
    Volume: 14, P: 483-485

  • Various neurodegenerative diseases are characterized by aggregates of pathological proteins, and increasing evidence suggests these disease-associated proteins may 'spread' via neuronal connections. Trojanowski and colleagues describe the molecular mechanisms of such spreading, and present the findings from neuropathological and imaging studies in humans that support this process.

    • Johannes Brettschneider
    • Kelly Del Tredici
    • John Q. Trojanowski
    Reviews
    Nature Reviews Neuroscience
    Volume: 16, P: 109-120