The kinase JNK is known to stimulate c-Jun transcriptional activity, but the molecular mechanism has been unclear. Here, N-terminal phosphorylation of c-Jun is shown to antagonize the interaction of c-Jun with Mbd3, a component of the repressor complex NuRD. The interaction between c-Jun and Mbd3 is shown to be important in regulating the proliferation of intestinal progenitor cells in mice.
- Cristina Aguilera
- Kentaro Nakagawa
- Axel Behrens