Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–24 of 24 results
Advanced filters: Author: Kevin D. Deane Clear advanced filters

  • That many autoimmune rheumatic diseases have an extended preclinical period, during which autoimmunity develops and evolves, is becoming apparent. In this Review, the authors discuss the current knowledge of the preclinical pathogenesis of rheumatoid arthritis and systemic lupus erythematosus, and use these diseases as models to highlight how such understanding could, in the future, improve therapeutic intervention and even lead to preventative approaches in autoimmune rheumatic diseases.

    • Kevin D. Deane
    • Hani El-Gabalawy
    Reviews
    Nature Reviews Rheumatology
    Volume: 10, P: 212-228

  • The presence of antibodies to citrullinated protein antigens (ACPA) in peripheral blood represents a risk a state that is ‘at-risk’ for subsequent development of rheumatoid arthritis (RA). Here authors compare multiple molecular and immunological parameters in individuals who are ACPA positive without inflammatory arthritis, ACPA negative controls and patients diagnosed with ACPA positive early-stage RA to conclude that complex immunopathological processes are present in an ACPA positive state which may be targeted by future preventive approaches for RA.

    • Eddie A. James
    • V. Michael Holers
    • Kevin D. Deane
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • Single-cell transcriptomic and proteomic data from synovial tissue from individuals with rheumatoid arthritis classify patients into groups based on abundance of cell states that can provide insights into pathology and predict individual treatment responses.

    • Fan Zhang
    • Anna Helena Jonsson
    • Soumya Raychaudhuri
    ResearchOpen Access
    Nature
    Volume: 623, P: 616-624

  • Fibroblasts play critical roles in tissue homeostasis, but in pathologic states they can drive fibrosis, inflammation, and tissue destruction. Here, Faust et al. find that healthy human synovial fibroblasts under the influence of adjacent adipocytes have altered lipid metabolism driven by cortisol signaling. Both adipocytes and these characteristics are lost in inflammatory arthritis.

    • Heather J. Faust
    • Tan-Yun Cheng
    • Michael B. Brenner
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • Activated B cells and T cells accumulate within joints of patients with rheumatoid arthritis. Here, the authors use single-cell transcriptome and repertoire profiling to identify clonally expanded synovial B cells and T cells and define their phenotypes and predicted cell-cell interactions.

    • Garrett Dunlap
    • Aaron Wagner
    • Jennifer H. Anolik
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21

  • In the development of rheumatoid arthritis, which factors govern the transition from systemic autoimmunity to synovitis? A study combining findings from human disease and animal models suggests that autoantibodies to neutrophil-derived citrullinated histone 2B are important for this transition; however, a 'second hit' involving intra-articular inflammation and citrullination could also be crucial to this process.

    • Kevin D. Deane
    News & Views
    Nature Reviews Rheumatology
    Volume: 11, P: 688-689

  • The immune mechanisms underlying synovitis and joint tissue destruction in rheumatoid arthritis (RA) remain incompletely defined. Here, the authors demonstrate that ACPA+ RA patients have activated clonally expanded cytotoxic GZMB+ CD8+ T cells in blood and synovium that target and are activated by citrullinated antigens to mediate cell killing.

    • Jae-Seung Moon
    • Shady Younis
    • William H. Robinson
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • A study finds that a protease called granzyme K can activate the entire complement cascade, explaining how it can drive destructive inflammation in inflammatory diseases such as rheumatoid arthritis.

    • Carlos A. Donado
    • Erin Theisen
    • Michael B. Brenner
    Research
    Nature
    Volume: 641, P: 211-221

  • The epigenetic changes underlying the heterogeneity of RA disease presentation have been the subject of intense scrutiny. In this study, the authors use multiple single-cell sequencing datasets to define ‘chromatin superstates’ in patients with RA, which associate with distinct transcription factors and disease phenotypes.

    • Kathryn Weinand
    • Saori Sakaue
    • Soumya Raychaudhuri
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-25

  • Insufficient AHR activation has been suggested in SLE, and augmenting AHR activation therapeutically may prevent CXCL13+ TPH/TFH differentiation and the subsequent recruitment of B cells and formation of lymphoid aggregates in inflamed tissues.

    • Calvin Law
    • Vanessa Sue Wacleche
    • Deepak A. Rao
    Research
    Nature
    Volume: 631, P: 857-866

  • Mass spectrometry fragmentation patterns define analytical barcodes for the rapid, quantitative analysis of high-throughput chemical synthesis experiments.

    • Maowei Hu
    • Lei Yang
    • Daniel J. Blair
    Research
    Nature
    Volume: 636, P: 374-379

  • The discovery that autoantibodies and other factors can predict the future onset of rheumatoid arthritis (RA) has encouraged the development of clinical trials looking at RA prevention. Although an exciting area of research, finding an approach that results in the successful completion of an RA prevention trial is challenging.

    • Liam J. O’Neil
    • Kevin D. Deane
    News & Views
    Nature Reviews Rheumatology
    Volume: 17, P: 385-386

  • Holers and colleagues review current data linking immune mechanisms and dysbiosis at distinct mucosal sites to risk of rheumatoid arthritis (RA). Their newly introduced causal mucosal endotypes hypothesis suggests that lung-, gut-, or oral-associated endotypes might drive the pathogenesis and progression of RA, and highlights associated research directions towards preventive and therapeutic strategies in RA.

    • V. Michael Holers
    • Kristen M. Demoruelle
    • Kevin D. Deane
    Reviews
    Nature Reviews Rheumatology
    Volume: 20, P: 601-613

  • In this Review, the authors summarize and discuss regional differences in the prevalence and incidence of rheumatoid arthritis (RA), and describe temporal trends associated with the disease as well as evidence related to risk factors.

    • Axel Finckh
    • Benoît Gilbert
    • Kim Lauper
    Reviews
    Nature Reviews Rheumatology
    Volume: 18, P: 591-602

  • Preclinical rheumatoid arthritis (RA) is characterized by the presence of RA-related autoantibodies in the serum in the absence of clinical symptoms. This Review discusses the relationships during this period between mucosal alterations and the initiation of local and systemic anti-citrullinated protein antibody production.

    • V. Michael Holers
    • M. Kristen Demoruelle
    • Kevin D. Deane
    Reviews
    Nature Reviews Rheumatology
    Volume: 14, P: 542-557