Nature Search

METTL3 safeguards cell identity and epigenome of human trophoblast stem cells

METTL3 promotes healthy placenta function by regulating m⁶A methylation and histone epigenetics. Deficiency in METTL3 leads to premature senescence, inflammation activation of trophoblasts, contributing to pregnancy complications like preeclampsia.

Haifeng Fu
Chunxiao Chen
Pentao Liu
ResearchOpen Access16 Dec 2025
Nature Communications

Volume: 17, P: 1-19
Spatial fibroblast niches define Crohn’s fistulae

Spatial transcriptomic analysis of cells in intestinal fistulae of patients with Crohn’s disease reveals the existence of specialized fistula-associated cell states with distinct signalling profiles and extracellular matrix architecture.

Colleen McGregor
Xiao Qin
Alison Simmons
ResearchOpen Access12 Nov 2025
Nature

Volume: 649, P: 703-712
Author Correction: Spatial fibroblast niches define Crohn’s fistulae

Colleen McGregor
Xiao Qin
Alison Simmons
Amendments and CorrectionsOpen Access25 Nov 2025
Nature

Volume: 648, P: E7
Phagocytosis-initiated tumor hybrid cells acquire a c-Myc-mediated quasi-polarization state for immunoevasion and distant dissemination

The CD47/SIRPα axis is well known to mediate immune escape by promoting cancer resistance to phagocytosis. Here the authors show that low CD47-expressing prostate cancer cells still allow phagocytosis but the process is incomplete leading to the formation of macrophage:tumor hybrid cells with immune evasive and pro-metastatic properties.

Chih-Wei Chou
Chia-Nung Hung
Tim Hui-Ming Huang
ResearchOpen Access17 Oct 2023
Nature Communications

Volume: 14, P: 1-20
Mechanistic insights into the versatile stoichiometry and biased signaling of the apelin receptor-arrestin complex

The apelin receptor regulates heart and metabolic health via G-protein and β-arrestin signaling pathways. Here, authors present receptor-β-arrestin complex structures with distinct stoichiometries that provide insight into biased signaling, guiding targeted drug design.

Yang Yue
Chanjuan Xu
Fei Xu
ResearchOpen Access11 Aug 2025
Nature Communications

Volume: 16, P: 1-12
Isolated iridium oxide sites on modified carbon nitride for photoreforming of plastic derivatives

The photocatalytic reforming of plastics into value-added chemicals offers a promising strategy to address environmental challenges while providing significant energy benefits. Here, the authors develop modified carbon nitride with enhanced visible light absorption, effectively anchoring under-coordinated IrN₂O₂ sites to catalyze the oxidation of persistent plastic derivatives.

Pawan Kumar
Hongguang Zhang
Md Golam Kibria
ResearchOpen Access24 Mar 2025
Nature Communications

Volume: 16, P: 1-17
BRD1 deficiency affects SREBF1-related lipid metabolism through regulating H3K9ac/H3K9me3 transition to inhibit HCC progression

Mingyang Zhang
Jing Bai
Changshan Wang
ResearchOpen Access17 Feb 2025
Cell Death & Disease

Volume: 16, P: 1-14
Peer effects on appropriate antibiotic prescribing within a patient-sharing physician network in China

Gong et al. explore how physicians influence one another’s antibiotic prescription likelihood by applying patient-sharing network methods. Their findings indicate that physicians are more likely to prescribe antibiotics appropriately when their peers had previously, with the effect being particularly pronounced among physicians highly central to the network.

Zhiwen Gong
Mengyuan Fu
Xiaodong Guan
ResearchOpen Access18 Nov 2025
Communications Medicine

Volume: 5, P: 1-9
Recognition of methamphetamine and other amines by trace amine receptor TAAR1

We report on the structures of the TAAR1–G-protein complex when bound to methamphetamine and other amines.

Heng Liu
You Zheng
Fei Xu
Research07 Nov 2023
Nature

Volume: 624, P: 663-671
Unraveling the causal genes and transcriptomic determinants of human telomere length

Variation in human telomere length has been well studied, but most previous studies have used adult telomere length. Here, the authors explore the genetic basis of telomere length in the placenta and find suggestive causal genes modulating human telomere length.

Ying Chang
Yao Zhou
Dandan Huang
ResearchOpen Access21 Dec 2023
Nature Communications

Volume: 14, P: 1-15
A novel protein encoded by circUBE2G1 suppresses glycolysis in gastric cancer through binding to ENO1

Lu Lu
Guoqing Guo
Xianghua Liu
ResearchOpen Access29 Jul 2025
Cell Death Discovery

Volume: 11, P: 1-13
Chemosensation of the pheromone spermine by the olfactory TAAR-like receptor TAAR348

Kexin Jiang
Liting Zeng
Fei Xu
CorrespondenceOpen Access27 Sept 2025
Cell Discovery

Volume: 11, P: 1-4
Activation of MAPK signaling pathway is essential for Id-1 induced serum independent prostate cancer cell growth

Ming-Tat Ling
Xianghong Wang
Y C Wong
Research04 Dec 2002
Oncogene

Volume: 21, P: 8498-8505
AXIN1 boosts antiviral response through IRF3 stabilization and induced phase separation

Dan-Ling Dai
Chu Xie
Mu-Sheng Zeng
ResearchOpen Access09 Oct 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-17
Polygenic risk modeling for prediction of epithelial ovarian cancer risk

Eileen O. Dareng
Jonathan P. Tyrer
Paul D. P. Pharoah
ResearchOpen Access14 Jan 2022
European Journal of Human Genetics

Volume: 30, P: 349-362
A reference equation for peak oxygen uptake for cycle ergometry in Chinese adult participants

Jinan Wang
Chuan Ren
Wei Zhao
ResearchOpen Access29 Mar 2025
Scientific Reports

Volume: 15, P: 1-11
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
Preliminary effectiveness of breast cancer screening among 1.22 million Chinese females and different cancer patterns between urban and rural women

Yubei Huang
Hongji Dai
Kexin Chen
ResearchOpen Access20 Dec 2016
Scientific Reports

Volume: 6, P: 1-10
Id-1 expression promotes cell survival through activation of NF-κB signalling pathway in prostate cancer cells

Ming-Tat Ling
Xianghong Wang
Yong-Chuan Wong
Research17 Jul 2003
Oncogene

Volume: 22, P: 4498-4508
Correction: Transcription factor EB-mediated mesenchymal stem cell therapy induces autophagy and alleviates spinocerebellar ataxia type 3 defects in neuronal cells model

Xiaobo Han
Jean de Dieu Habimana
Zhiyuan Li
Amendments and CorrectionsOpen Access28 Jul 2022
Cell Death & Disease

Volume: 13, P: 1
Integrative analysis identifies the atypical repressor E2F8 as a targetable transcriptional activator driving lethal prostate cancer

Furong Huang
Kexin Li
Qianben Wang
Research29 Nov 2024
Oncogene

Volume: 44, P: 481-493
Assessing causal relationship between circulating cytokines and age-related neurodegenerative diseases: a bidirectional two-sample Mendelian randomization analysis

Zihan Yin
Jiao Chen
Fanrong Liang
ResearchOpen Access29 Jul 2023
Scientific Reports

Volume: 13, P: 1-10
Transcription factor EB-mediated mesenchymal stem cell therapy induces autophagy and alleviates spinocerebellar ataxia type 3 defects in neuronal cells model

Xiaobo Han
Jean de Dieu Habimana
Zhiyuan Li
ResearchOpen Access18 Jul 2022
Cell Death & Disease

Volume: 13, P: 1-12
Correction: Polygenic risk modeling for prediction of epithelial ovarian cancer risk

Eileen O. Dareng
Jonathan P. Tyrer
Paul D. P. Pharoah
Amendments and CorrectionsOpen Access22 Mar 2022
European Journal of Human Genetics

Volume: 30, P: 630-631

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