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Showing 1–2 of 2 results
Advanced filters: Author: Khalissa Rahmani Clear advanced filters
  • Previous research has suggested that pDCs are required for an effective antiviral immune response, but direct experimental evidence to support this is lacking. Here Ngo et al. develop a pDC knockin mouse model and find that pDCs are dispensable for an antiviral immune response to mouse cytomegalovirus and may be detrimental during influenza or SARS-CoV-2 infection.

    • Clemence Ngo
    • Camille Pierini-Malosse
    • Elena Tomasello
    ResearchOpen Access
    Nature Immunology
    Volume: 26, P: 1962-1976
  • Dalod and colleagues utilize a combinatorial genetic reporter strategy to uniquely mark plasmacytoid dendritic cells (pDCs) in mice. They utilize these mice to identify bona fide pDCs and functionally characterize before and during viral infection, in comparison to several other DC types.

    • Michael Valente
    • Nils Collinet
    • Marc Dalod
    ResearchOpen Access
    Nature Immunology
    Volume: 24, P: 714-728