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Showing 1–5 of 5 results
Advanced filters: Author: Kim Fabiano Marquart Clear advanced filters

  • Pancreatic cancer is characterized by an immunosuppressive microenvironment, leading to immune evasion. Here, based on in vitro and in vivo CRISPR screens, the authors identify Rnf31 and Vps4b as drivers of immune escape, showing that loss of their function leads to an increase in T cell-mediated killing and reduced tumor growth in preclinical pancreatic cancer models.

    • Nina Frey
    • Luigi Tortola
    • Gerald Schwank
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Through directed evolution, the PAM compatibility of the compact Cas9 variant CjCas9 was increased. Evolved CjCas9 shows higher nuclease activity at canonical and non-canonical sites and enables robust in vivo gene editing from single AAV vectors.

    • Lukas Schmidheini
    • Nicolas Mathis
    • Gerald Schwank
    Research
    Nature Chemical Biology
    Volume: 20, P: 333-343