Therapies that target only one inflammatory cytokine such as tumor necrosis factor α are often insufficient to treat rheumatoid arthritis. Aikawa et al. show that a small molecule targeting c-Fos/AP-1, a transcription factor that regulates both inflammatory cytokines and matrix metalloproteinases, inhibits type II collagen-induced arthritis in mice.
- Yukihiko Aikawa
- Kimiko Morimoto
- Shunichi Shiozawa
