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Brain change trajectories in healthy adults correlate with Alzheimer’s related genetic variation and memory decline across life

This study shows that among healthy adults tracked across their lives, brain atrophy rates correlate with genetic risk for Alzheimer’s and memory decline, and that degeneration in Alzheimer’s-vulnerable brain regions is a continuous phenomenon.

James M. Roe
Didac Vidal-Piñeiro
Yunpeng Wang
ResearchOpen Access17 Dec 2024
Nature Communications

Volume: 15, P: 1-19
Association of gout with brain reserve and vulnerability to neurodegenerative disease

The potential association between neurodegenerative disease risk and gout is not fully understood. Here the authors showed that gout is causally related to several measures of brain structure which may explain their higher vulnerability to dementia.

Anya Topiwala
Kulveer Mankia
Thomas E. Nichols
ResearchOpen Access18 May 2023
Nature Communications

Volume: 14, P: 1-9
Nuclei-specific hypothalamus networks predict a dimensional marker of stress in humans

The association between connectivity of the hypothalamus and stress is not well understood. Here, the authors show connectivity between hypothalamic nuclei and other subcortical structures is predictive of stress.

Daria E. A. Jensen
Klaus P. Ebmeier
Miriam C. Klein-Flügge
ResearchOpen Access18 Mar 2024
Nature Communications

Volume: 15, P: 1-19
No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy

Fjell et al. analysed multiple large-scale longitudinal MRI datasets and found no evidence for an association of sleep duration and brain atrophy, suggesting that normal brains promote adequate sleep.

Anders M. Fjell
Øystein Sørensen
Kristine B. Walhovd
ResearchOpen Access05 Oct 2023
Nature Human Behaviour

Volume: 7, P: 2008-2022
No significant association between self-reported physical activity and brain volumes in women and men from five European cohorts

Naiara Demnitz
William F. C. Baaré
Carl-Johan Boraxbekk
ResearchOpen Access30 May 2025
Scientific Reports

Volume: 15, P: 1-9
5-HT Modulation of Dopamine Release in Basal Ganglia in Psilocybin-Induced Psychosis in Man—A PET Study with [¹¹C]raclopride

Franz X Vollenweider
Peter Vontobel
Klaus L Leenders
Research01 May 1999
Neuropsychopharmacology

Volume: 20, P: 424-433
Brain aging differs with cognitive ability regardless of education

Kristine B. Walhovd
Lars Nyberg
Anders M. Fjell
ResearchOpen Access16 Aug 2022
Scientific Reports

Volume: 12, P: 1-12
Allostatic load as a predictor of grey matter volume and white matter integrity in old age: The Whitehall II MRI study

Enikő Zsoldos
Nicola Filippini
Klaus P. Ebmeier
ResearchOpen Access23 Apr 2018
Scientific Reports

Volume: 8, P: 1-11

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