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Showing 1–50 of 53 results

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Author Correction: GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region

Yuki Ishikawa
Nao Tanaka
Chikashi Terao
Amendments and CorrectionsOpen Access19 Jan 2026
Nature Communications

Volume: 17, P: 1
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
In vitro effects on microtubule dynamics of purified Xenopus M phase-activated MAP kinase

Yukiko Gotoh
Eisuke Nishida
Hikoichi Sakai
Research17 Jan 1991
Nature

Volume: 349, P: 251-254
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Single-molecule methods for characterizing receptor dimers reveal metastable opioid receptor homodimers that induce functional modulation

Receptor dimerization is central to many GPCRs signaling, but key rate and equilibrium constants are hard to measure. Here, the authors present single-molecule methods to obtain such constants and reveal transient opioid receptor homodimers modulating function.

Peng Zhou
Taka A. Tsunoyama
Akihiro Kusumi
ResearchOpen Access07 Nov 2025
Nature Communications

Volume: 16, P: 1-23
GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region

Here, the authors identify six risk SNPs for systemic sclerosis by performing GWAS on Japanese patients and meta-analyzing Japanese and European GWAS datasets. Downstream analyses indicate that B cells contribute to pathogenesis.

Yuki Ishikawa
Nao Tanaka
Chikashi Terao
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-16
Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease

Genome-wide association analyses in the Japanese population and trans-ancestry meta-analyses identify new risk loci for coronary artery disease. A polygenic risk score derived from these findings identifies individuals with increased risk of long-term cardiovascular mortality.

Satoshi Koyama
Kaoru Ito
Issei Komuro
Research05 Oct 2020
Nature Genetics

Volume: 52, P: 1169-1177
Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis

Multi-ancestry genome-wide association analyses identify 124 risk loci for rheumatoid arthritis, of which 34 are novel. A polygenic risk score based on multi-ancestry data showed comparable performance between populations of European and East Asian ancestries.

Kazuyoshi Ishigaki
Saori Sakaue
Soumya Raychaudhuri
Research04 Nov 2022
Nature Genetics

Volume: 54, P: 1640-1651
Moiré band engineering in twisted trilayer WSe₂

Twisted trilayer transition metal dichalcogenides present complex moiré patterns that can lead to unique electronic properties not seen in bilayers. Here, the authors use a continuum approach to reveal that lattice relaxation in trilayer WSe₂ results in distinct domain arrangements and band structures according to the twist configurations -" Kagome flat bands for helical trilayers or strongly confined quantum wells for alternating trilayers -" offering a versatile platform for tunable electronic and excitonic behaviors.

Naoto Nakatsuji
Takuto Kawakami
Mikito Koshino
ResearchOpen Access28 Nov 2025
Communications Materials

Volume: 6, P: 1-17
Time-averaged disease activity fits better joint destruction in rheumatoid arthritis

Hideaki Tsuji
Koichiro Yano
Chikashi Terao
ResearchOpen Access19 Jul 2017
Scientific Reports

Volume: 7, P: 1-8
Chaperonin turned insect toxin

Naofumi Yoshida
Kenji Oeda
Kazuhiko Matsuda
Research03 May 2001
Nature

Volume: 411, P: 44
Long-term outcomes after endoscopic retrograde pancreatic drainage for symptomatic pancreaticojejunal anastomotic stenosis

Akihiko Kida
Yukihiro Shirota
Tokio Wakabayashi
ResearchOpen Access24 Feb 2021
Scientific Reports

Volume: 11, P: 1-8
ATP dynamics as a predictor of future podocyte structure and function after acute ischemic kidney injury in female mice

The involvement of glomerular injury in acute kidney injury (AKI) has not been fully elucidated. Here, authors visualize impaired ATP recovery in podocytes in a murine model of ischemic AKI using intravital ATP imaging and propose accelerated mitochondrial fission as a key factor of ischemic podocyte injury.

Masahiro Takahashi
Shinya Yamamoto
Motoko Yanagita
ResearchOpen Access22 Nov 2024
Nature Communications

Volume: 15, P: 1-19
Whole-genome sequencing of 3135 individuals representing the genetic diversity of the Japanese population

Koichiro Higasa
Yoichiro Kamatani
Fumihiko Matsuda
ResearchOpen Access08 Nov 2025
Journal of Human Genetics

P: 1-8
Precision cancer genome testing needs proficiency testing involving all stakeholders

Masato Maekawa
Terumi Taniguchi
Moriya Iwaizumi
ResearchOpen Access27 Jan 2022
Scientific Reports

Volume: 12, P: 1-7
Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation

Matsuo et al. report that thiazoline-related innate fear-eliciting compounds activate the spinal trigeminal nucleus (Sp5) and the nucleus of the solitary tract (NTS) via vagal/trigeminal TRPA1 to induce robust physiological alterations, enabling long time survival in a lethal hypoxic environment.

Tomohiko Matsuo
Tomoko Isosaka
Ko Kobayakawa
ResearchOpen Access06 Apr 2021
Nature Communications

Volume: 12, P: 1-17
Pioglitazone Lowers Systemic Asymmetric Dimethylarginine by Inducing Dimethylarginine Dimethylaminohydrolase in Rats

Shu Wakino
Koichi Hayashi
Takao Saruta
Research01 Mar 2005
Hypertension Research

Volume: 28, P: 255-262
Association of ALPL variants with serum alkaline phosphatase and bone traits in the general Japanese population: The Nagahama Study

Miho Nagata
Kazuya Setoh
Shinji Kosugi
Research20 Dec 2019
Journal of Human Genetics

Volume: 65, P: 337-343
Causes of Death in Patients with Severe Aortic Stenosis: An Observational study

Eri Minamino-Muta
Takao Kato
Takeshi Kimura
ResearchOpen Access07 Nov 2017
Scientific Reports

Volume: 7, P: 1-6
Effect of Systemic Nitric Oxide Synthase Inhibition on Arterial Stiffness in Humans

Jun Sugawara
Hidehiko Komine
Hirofumi Tanaka
Research01 May 2007
Hypertension Research

Volume: 30, P: 411-415
Effects of Angiotensin II Type 1 Receptor Blockade on the Systemic Blood Nitric Oxide Dynamics in N^ω-Nitro-L-Arginine Methyl Ester–Treated Rats

Yasuhisa Kanematsu
Koichiro Tsuchiya
Toshiaki Tamaki
Research01 May 2006
Hypertension Research

Volume: 29, P: 369-374
The medaka draft genome and insights into vertebrate genome evolution

The medaka fish (Oryzias latipes) has long been a popular pet in Japan and more recently a laboratory model organism; it now has its genome sequenced and analysed by a Japanese consortium.

Masahiro Kasahara
Kiyoshi Naruse
Yuji Kohara
ResearchOpen Access07 Jun 2007
Nature

Volume: 447, P: 714-719
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Arid5b facilitates chondrogenesis by recruiting the histone demethylase Phf2 to Sox9-regulated genes

The transcription factor Sox9 together with its co-regulators promotes chondrocyte differentiation. Here Hata et al.find that Arid5b acts as a transcriptional co-regulator of Sox9 by regulating histone demethylation of Sox9 target genes during chondrogenesis in mice.

Kenji Hata
Rikako Takashima
Toshiyuki Yoneda
Research26 Nov 2013
Nature Communications

Volume: 4, P: 1-11
Early prediction of functional impairment at hospital discharge in patients with osteoporotic vertebral fracture: a machine learning approach

Soichiro Masuda
Toshiki Fukasawa
Koji Kawakami
ResearchOpen Access28 Dec 2024
Scientific Reports

Volume: 14, P: 1-10
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Primary open-angle glaucoma (POAG) is highly heritable, yet not well understood from a genetic perspective. Here, the authors perform a meta-analysis of genome-wide association studies in 34,179 POAG cases, identifying 44 previously unreported risk loci and mapping effects across multiple ethnicities.

Puya Gharahkhani
Eric Jorgenson
Janey L. Wiggs
ResearchOpen Access24 Feb 2021
Nature Communications

Volume: 12, P: 1-16
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population

Yuta Kochi and colleagues report a meta-analysis of genome-wide association studies for rheumatoid arthritis in a Japanese population. They identify nine loci newly associated with rheumatoid arthritis in this population and consider overlap of associations with previous studies in European populations.

Yukinori Okada
Chikashi Terao
Kazuhiko Yamamoto
Research25 Mar 2012
Nature Genetics

Volume: 44, P: 511-516
Anti-centromere antibody exhibits specific distribution levels among anti-nuclear antibodies and may characterize a distinct subset in rheumatoid arthritis

Nobuo Kuramoto
Koichiro Ohmura
Chikashi Terao
ResearchOpen Access31 Jul 2017
Scientific Reports

Volume: 7, P: 1-8
Structural re-evaluation of the human gluteus maximus

Hidaka Anetai
Kota Kato
Koichiro Ichimura
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-11
Genetics of rheumatoid arthritis contributes to biology and drug discovery

A genome-wide association study meta-analysis of more than 100,000 subjects of European and Asian ancestries reveals 42 new risk loci for rheumatoid arthritis, with follow-up studies identifying 98 biological candidate genes that are either already being targeted by drugs or could be in the future.

Yukinori Okada
Di Wu
Robert M. Plenge
Research25 Dec 2013
Nature

Volume: 506, P: 376-381
A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility

Yuta Kochi and colleagues identify a regulatory variant in CCR6 associated with susceptibility to rheumatoid arthritis. CCR6 encodes a chemokine receptor expressed on a subset of helper T cells known as Th17 cells, suggesting a possible role for CCR6 in Th17-driven autoimmunity.

Yuta Kochi
Yukinori Okada
Kazuhiko Yamamoto
Research09 May 2010
Nature Genetics

Volume: 42, P: 515-519
Sedentary behaviour may cause differences in physical outcomes and activities of daily living in older cardiovascular disease patients participating in phase I cardiac rehabilitation

Kazuhiro P. Izawa
Kodai Ishihara
Ikki Shimizu
ResearchOpen Access18 Jun 2024
Scientific Reports

Volume: 14, P: 1-9
Publisher Correction: Genome-wide association study of individual differences of human lymphocyte profiles using large-scale cytometry data

Daigo Okada
Naotoshi Nakamura
Ryo Yamada
Amendments and Corrections15 Jan 2021
Journal of Human Genetics

Volume: 66, P: 643
Significant association between CYP3A5 polymorphism and blood concentration of tacrolimus in patients with connective tissue diseases

Kosuke Tanaka
Chikashi Terao
Fumihiko Matsuda
Research19 Dec 2013
Journal of Human Genetics

Volume: 59, P: 107-109
Clinical and endocrine features of orthostatic intolerance detected in patients with long COVID

Atsushi Kato
Kazuki Tokumasu
Fumio Otsuka
ResearchOpen Access24 Jul 2024
Scientific Reports

Volume: 14, P: 1-10
Identification of epistatic SNP combinations in rheumatoid arthritis using LAMPLINK and Japanese cohorts

Mio Shibata
Aika Terada
Ryo Yamada
Research16 Jul 2024
Journal of Human Genetics

Volume: 69, P: 541-547
Anemia in Patients with Severe Aortic Stenosis

Kazuya Nagao
Tomohiko Taniguchi
Mitsuru Kitano
ResearchOpen Access13 Feb 2019
Scientific Reports

Volume: 9, P: 1-11
Asymptomatic versus Symptomatic Patients with Severe Aortic Stenosis

Norio Kanamori
Tomohiko Taniguchi
Mitsuru Kitano
ResearchOpen Access04 Jul 2018
Scientific Reports

Volume: 8, P: 1-10
Exploring effective biomarkers and potential immune related gene in small cell lung cancer

Yang Yunchu
Akihiko Miyanaga
Masahiro Seike
ResearchOpen Access31 Mar 2024
Scientific Reports

Volume: 14, P: 1-12
Multidimensional analyses of the pathomechanism caused by the non-catalytic GNE variant, c.620A>T, in patients with GNE myopathy

Wakako Yoshioka
Aritoshi Iida
Ichizo Nishino
ResearchOpen Access16 Dec 2022
Scientific Reports

Volume: 12, P: 1-11
Habitual fish intake negatively correlates with prevalence of frailty among patients with rheumatoid arthritis

Hiroto Minamino
Masao Katsushima
Shuichi Matsuda
ResearchOpen Access03 Mar 2021
Scientific Reports

Volume: 11, P: 1-9
Population dynamics in the Japanese Archipelago since the Pleistocene revealed by the complete mitochondrial genome sequences

Fuzuki Mizuno
Jun Gojobori
Shintaroh Ueda
ResearchOpen Access13 Jun 2021
Scientific Reports

Volume: 11, P: 1-11
Human genetic variation database, a reference database of genetic variations in the Japanese population

Koichiro Higasa
Noriko Miyake
Fumihiko Matsuda
ResearchOpen Access25 Feb 2016
Journal of Human Genetics

Volume: 61, P: 547-553
EYS is a major gene involved in retinitis pigmentosa in Japan: genetic landscapes revealed by stepwise genetic screening

Shogo Numa
Akio Oishi
Akitaka Tsujikawa
ResearchOpen Access27 Nov 2020
Scientific Reports

Volume: 10, P: 1-9
Genome-wide association study of individual differences of human lymphocyte profiles using large-scale cytometry data

Daigo Okada
Naotoshi Nakamura
Ryo Yamada
ResearchOpen Access23 Nov 2020
Journal of Human Genetics

Volume: 66, P: 557-567
Genetic basis for plasma amino acid concentrations based on absolute quantification: a genome-wide association study in the Japanese population

Akira Imaizumi
Yusuke Adachi
Fumihiko Matsuda
ResearchOpen Access18 Jan 2019
European Journal of Human Genetics

Volume: 27, P: 621-630
Intrarenal Doppler ultrasonography reflects hemodynamics and predicts prognosis in patients with heart failure

Akiomi Yoshihisa
Koichiro Watanabe
Yasuchika Takeishi
ResearchOpen Access17 Dec 2020
Scientific Reports

Volume: 10, P: 1-9

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