Nature Search

RO4938581, a GABA_A-α5 negative allosteric modulator rescued behavioral and EEG phenotypes of a mouse model of Dup15q syndrome

Ryoko Nakagawa
Francesca Nani
Maria-Clemencia Hernandez
ResearchOpen Access05 Jan 2026
Molecular Psychiatry

P: 1-10
Duplication of the autism-related gene Chd8 leads to behavioral hyperactivity and neurodevelopmental defects in mice

Chd8 knock-in mice modeling human CHD8 duplication exhibit growth retardation, microcephaly, and hyperactive behavior. Here authors show CHD8 overexpression causes abnormal binding to enhancers, leading to disrupted regulation of genes involved in brain development.

Atsuki Kawamura
Kazuki Fujii
Masaaki Nishiyama
ResearchOpen Access26 May 2025
Nature Communications

Volume: 16, P: 1-19
Remodeling of the postsynaptic proteome in male mice and marmosets during synapse development

The proteomic changes that occur during synapse development are not fully understood. In this work, the authors characterise the postsynaptic proteome changes that occur during development in male mice and marmosets.

Takeshi Kaizuka
Takehiro Suzuki
Toru Takumi
ResearchOpen Access28 Mar 2024
Nature Communications

Volume: 15, P: 1-17
Genetic dissection identifies Necdin as a driver gene in a mouse model of paternal 15q duplications

Duplication of chromosome 15q11-q13 is associated with autism spectrum disorder (ASD). Here, the authors show that in mice paternal Dup15q results in ASD-like neuronal and behavioural impairment driven by Necdin.

Kota Tamada
Keita Fukumoto
Toru Takumi
ResearchOpen Access01 Jul 2021
Nature Communications

Volume: 12, P: 1-16
A common epigenetic mechanism across different cellular origins underlies systemic immune dysregulation in an idiopathic autism mouse model

Chia-Wen Lin
Dian E. Septyaningtrias
Toru Takumi
Research02 May 2022
Molecular Psychiatry

Volume: 27, P: 3343-3354
Increased self-triggered vocalizations in an epidermal growth factor-induced rat model for schizophrenia

Itaru Narihara
Hanako Yokoyama
Hiroyuki Nawa
ResearchOpen Access28 Jul 2022
Scientific Reports

Volume: 12, P: 1-12
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

Michiru Nishita
Seung-Yeol Park
Yasuhiro Minami
ResearchOpen Access26 Jan 2017
Scientific Reports

Volume: 7, P: 1-15
An old model with new insights: endogenous retroviruses drive the evolvement toward ASD susceptibility and hijack transcription machinery during development

Chia-Wen Lin
Jacob Ellegood
Toru Takumi
ResearchOpen Access07 Mar 2023
Molecular Psychiatry

Volume: 28, P: 1932-1945
Citizen science via social media revealed conditions of symbiosis between a marine gastropod and an epibiotic alga

Osamu Kagawa
Shota Uchida
Ryoya Sugimoto
ResearchOpen Access12 Nov 2020
Scientific Reports

Volume: 10, P: 1-10

Search

RO4938581, a GABA_A-α5 negative allosteric modulator rescued behavioral and EEG phenotypes of a mouse model of Dup15q syndrome

Duplication of the autism-related gene Chd8 leads to behavioral hyperactivity and neurodevelopmental defects in mice

Remodeling of the postsynaptic proteome in male mice and marmosets during synapse development

Genetic dissection identifies Necdin as a driver gene in a mouse model of paternal 15q duplications

A common epigenetic mechanism across different cellular origins underlies systemic immune dysregulation in an idiopathic autism mouse model

Increased self-triggered vocalizations in an epidermal growth factor-induced rat model for schizophrenia

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

An old model with new insights: endogenous retroviruses drive the evolvement toward ASD susceptibility and hijack transcription machinery during development

Citizen science via social media revealed conditions of symbiosis between a marine gastropod and an epibiotic alga

Search

Quick links

Search

Filter By:

Search

Quick links