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Showing 1–3 of 3 results
Advanced filters: Author: Kristen M. Demoruelle Clear advanced filters

  • The presence of antibodies to citrullinated protein antigens (ACPA) in peripheral blood represents a risk a state that is ‘at-risk’ for subsequent development of rheumatoid arthritis (RA). Here authors compare multiple molecular and immunological parameters in individuals who are ACPA positive without inflammatory arthritis, ACPA negative controls and patients diagnosed with ACPA positive early-stage RA to conclude that complex immunopathological processes are present in an ACPA positive state which may be targeted by future preventive approaches for RA.

    • Eddie A. James
    • V. Michael Holers
    • Kevin D. Deane
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • Holers and colleagues review current data linking immune mechanisms and dysbiosis at distinct mucosal sites to risk of rheumatoid arthritis (RA). Their newly introduced causal mucosal endotypes hypothesis suggests that lung-, gut-, or oral-associated endotypes might drive the pathogenesis and progression of RA, and highlights associated research directions towards preventive and therapeutic strategies in RA.

    • V. Michael Holers
    • Kristen M. Demoruelle
    • Kevin D. Deane
    Reviews
    Nature Reviews Rheumatology
    Volume: 20, P: 601-613

  • Preclinical rheumatoid arthritis (RA) is characterized by the presence of RA-related autoantibodies in the serum in the absence of clinical symptoms. This Review discusses the relationships during this period between mucosal alterations and the initiation of local and systemic anti-citrullinated protein antibody production.

    • V. Michael Holers
    • M. Kristen Demoruelle
    • Kevin D. Deane
    Reviews
    Nature Reviews Rheumatology
    Volume: 14, P: 542-557