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Showing 1–11 of 11 results
Advanced filters: Author: Kristin Huntoon Clear advanced filters

  • Macrophage-dependent phagocytosis elicits robust antitumor immunity. Nevertheless, therapeutic strategies harnessing phagocytosis have been met with limited success. Here the authors demonstrate that dual-phagocytosis checkpoint blockade, achieved by simultaneously targeting CD47 and CD24, greatly enhances tumor cell phagocytosis thus increasing antigen-presentation capacity, cGAS-STING activation and T cell infiltration into the tumor microenvironment, ultimately fostering robust antitumor immunity in preclinical mouse models of glioblastoma.

    • JongHoon Ha
    • Yifan Wang
    • Wen Jiang
    ResearchOpen Access
    Nature Communications
    P: 1-12

  • Solid tumours are less responsive to immunotherapies than haematological tumours due to specific biological differences. In this paper the authors propose a strategy to decorate the cell membrane of solid tumours with a protein typically present on haematological tumour cells that promotes phagocytosis of cancer cells, and show that this results in an increased immunotherapy efficacy in animal models of solid tumours.

    • Yifei Lu
    • Kristin Huntoon
    • Wen Jiang
    Research
    Nature Nanotechnology
    Volume: 17, P: 1332-1341

  • Here, the authors find a decrease in hepatic phagocytic uptake of nanoparticles in old mice due to age-associated downregulation of the scavenger receptor MARCO, which led to improved tumour delivery and antitumour efficacy of cancer nanomedicine, showing the need to consider age as a factor in therapeutics.

    • Yifan Wang
    • Weiye Deng
    • Wen Jiang
    Research
    Nature Nanotechnology
    Volume: 19, P: 255-263

  • Activation of the STING pathway in antigen-presenting cells has been proposed as a strategy to stimulate the adaptive immune response against tumours, but its clinical application is hampered by the instability, low specificity and low cytosolic entry of natural STING agonists. Here the authors present a platform for targeted ultrasound-mediated cytosolic delivery of STING agonists that shows efficacy in different animal tumour models and improves the response to checkpoint blockade therapies.

    • Xuefeng Li
    • Sina Khorsandi
    • Jacques Lux
    Research
    Nature Nanotechnology
    Volume: 17, P: 891-899

  • There is an emerging interest in the use of mRNA therapeutics in cancer treatment, but their precise in vivo delivery remains a challenge. Here the authors develop IFN-γ mRNA-loaded small extracellular vesicles (sEVs) with CD64 overexpressed on their surface and demonstrate its efficacy in glioblastoma mouse models resistant to immunotherapy.

    • Shiyan Dong
    • Xuan Liu
    • Wen Jiang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Glioblastoma (GBM) is an immune cold tumour that is refractory to immunotherapy. Here, the authors identify molecular phenotypes of immune-suppressive and -promoting myeloid cells in GBM through single cell RNA sequencing and propose S100A4 as a regulator of immune suppressive T and myeloid cells in GBM.

    • Nourhan Abdelfattah
    • Parveen Kumar
    • Kyuson Yun
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • Physical properties affect immune signalling and effector functions in distinct immune cell subtypes. This Review discusses the impact of engineering nanomaterial physical characteristics on modulating immune responses and thus promoting efficient and effective cancer immunotherapy.

    • DaeYong Lee
    • Kristin Huntoon
    • Wen Jiang
    Reviews
    Nature Reviews Bioengineering
    Volume: 1, P: 499-517