Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–10 of 10 results
Advanced filters: Author: Kuglae Kim Clear advanced filters

  • Glutamine addiction is a hallmark of many cancers. iMQT_020, a first-in-class allosteric inhibitor of the mitochondrial glutamine transporter SLC1A5_var, disrupts glutamine-dependent mitochondrial metabolism, selectively killing cancer cells and enhancing immune checkpoint inhibitor efficacy.

    • Yulseung Sung
    • Ya Chun Yu
    • Jung Min Han
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-25

  • Biased signaling in κ-opiod receptors (KOR) offer an attractive strategy for pain management. Here the authors identify determinants of KOR signaling bias using structural methods in combination with molecular dynamics simulations.

    • Amal El Daibani
    • Joseph M. Paggi
    • Tao Che
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • The authors present 7 cryo-EM structures of hallucinogenic and non-hallucinogenic compounds across multiple chemotypes bound to the 5-HT2A receptor, shedding light onto ligand specificity and signaling bias.

    • Ryan H. Gumpper
    • Manish K. Jain
    • Bryan L. Roth
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Using cryo-EM, authors reveal the structure and activation mechanism of GPR156, a class C orphan GPCR implicated in sound detection. They find that GPR156 is a transducer for phospholipid signaling and provide insights into the basis for its constitutive activation.

    • Jinwoo Shin
    • Junhyeon Park
    • Yunje Cho
    Research
    Nature Structural & Molecular Biology
    Volume: 31, P: 678-687

  • Structural studies of the itch receptors MRGPRX2 and MRGPRX4 in complex with endogenous and synthetic ligands provide a basis for the development of therapeutic compounds for pain, itch and mast cell-mediated hypersensitivity.

    • Can Cao
    • Hye Jin Kang
    • Bryan L. Roth
    Research
    Nature
    Volume: 600, P: 170-175

  • This comprehensive study of the most enigmatic serotonin receptor 5-HT5AR includes lots of pharmacological investigations, inactive and active state structures with antagonist, partial agonist and full agonists. Also, a highly potent and selective antagonist was developed.

    • Shicheng Zhang
    • He Chen
    • Bryan L. Roth
    Research
    Nature Structural & Molecular Biology
    Volume: 29, P: 677-687

  • Recent studies revealed that G protein-coupled receptors rapidly interconvert between multiple states. Here, authors use the kappa opioid receptor (KOR) and show how two state-dependent nanobodies provide real-time reporting of ligand stabilized states with KOR and other GPCRs.

    • Tao Che
    • Justin English
    • Bryan L. Roth
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12