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The performance of flexible all-perovskite tandem solar cells remains limited by interfacial losses in narrow-bandgap subcells. Here, authors incorporate Triton X-100 to disrupt the vertical phase segregation in PEDOT:PSS films, achieving maximum cell and mini-module efficiencies of 25.4% and 19.7%.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

The ALICE Collaboration provides details on the microscopic mechanism that ends up creating antideuteron in high-energy proton–proton collisions at the Large Hadron Collider.

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Construction of chiral nanostructures is impeded by the entropic barrier of dissymmetric blocks. Here, the authors report a dynamic assembly/disassembly strategy to yield single-unit organometallic helices for enantioselective amyloid inhibition.

This study reports an adsorption-independent O₂ activation pathway for superior ¹O₂ electrosynthesis via an O₂ mono-hydrogenation process on compressive-strained rutile TiO₂. The compressive-strained TiO₂ suppresses the formation of reductive unsaturated sites for O₂ adsorption and enhances the reductive ability of atomic hydrogen, thereby enabling direct O₂ hydrogenation into free ^•OOH without the O₂ adsorption.

Zhao, Yang et al. used UK Biobank data to examine the role of lifestyle factors in depression. They conducted multiple analyses and estimated underlying mechanisms related to brain structure, immunometabolism and genetics.

In chronic myelogenous leukemia, leukemia stem cell function requires a microRNA that is provided by bone marrow endothelial cells.

Using multi-omics analysis, Zuo, Zhao, Wu, Wang, Wang and colleagues report disrupted branched-chain amino acid (BCAA) catabolism in skeletal muscle samples from patients with sarcopenia. In mouse models, they causally link BCAA catabolic dysfunction to impaired muscle mass and demonstrate the translational potential of enhancing BCAA catabolism.

Axially chiral compounds are commonly found in nature. Here, the authors show the highly enantioselective construction of axially chiral biaryls via an N-heterocyclic carbenes-catalyzed [3+3] atroposelective annulation of ynals with cyclic 1,3-diones.

The phase transitions of rare earth nickelates have attracted intensive study as they arise from the complex interplay of charge, spin and lattice degrees of freedom. Here Guo et al. present evidence that LaNiO₃ has an unanticipated magnetically ordered metallic phase.

MASLD is a growing global health concern. Here, the authors define a senescent hepatocyte gene signature (SHGS), demonstrate its clinical relevance, and identify senolytic therapies that selectively eliminate SHGS+ hepatocytes to improve MASLD and systemic health.

Rhombohedral-stacked molybdenum disulfide with sliding ferroelectric behaviour can be used to create atomically thin ferroelectric transistors for computing-in-memory device applications.

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

Spatially resolved images of M87 obtained at a wavelength of 3.5 mm in 2018 show a ring-like accretion structure, the inner (outer) edge of which connects the black hole (jet).

Body cavity macrophages reside on the serous surfaces of organs and believed to participate in organ repair following injury. Here the authors show with a fate-mapping reporter system that these cells, although accumulate at the surfaces of injured liver or lung, don’t penetrate deeply into the tissue.

Membrane fouling during electrodialysis, nanofiltration and ultrafiltration processes results in a reduction in the dye/salt fractionation efficacy. Here, authors devise an electro-driven filtration process using tight ion-conductive ultrafiltration membrane for one-step, stable dye/salt fractionation.

Acquired miR-142 deficit in leukemic stem cells has been associated with chronic myeloid leukemia blast crisis. Here the authors show that acquired miR-142 deficit in T cells further enables leukemic stem cells to escape immune surveillance and supports disease growth.

Together with a companion paper, the generation of a transcriptomic atlas for the mouse lemur and analyses of example cell types establish this animal as a molecularly tractable primate model organism.

Polluted continental aerosols contain a considerable fraction of ice nucleating particles, suggest analyses of satellite observations and simulations with cloud-resolving models.

miR-126 is highly expressed in inv(16) Acute myeloid leukemia (AML) but its role is unclear. Here, the authors show that the aberrant expression of miR-126 in inv(16) AML is directly due to the CBFB-MYH11 fusion gene and that it can promote AML development and leukemia stem cell maintenance, highlighting miR-126 as a therapeutic target for inv(16) AML patients

Endocrinologists have traditionally focused on studying one hormone or organ system at a time. Here the authors use transcriptomic data from the mouse lemur to globally characterize primate hormonal signaling, describing hormone sources and targets, identifying conserved and primate specific regulation, and elucidating principles of the network.

Sodium-ion batteries face challenges due to electrode degradation and interphase instability. Here, authors develop a smart gel polymer electrolyte for hard carbon||NaNi_1/3Fe_1/3Mn_1/3O₂ batteries via in situ polymerization of specific monomers in conventional electrolytes.

Isolation of individual cells from mixed populations is desirable for many biomedical applications. Here the authors use photoswitchable Pdots to allow 'optical painting', where cells of interest are marked based on their visual characteristics, and can then be isolated by fluorescence activated cell sorting.

Electrochemical nitrate reduction to ammonia offers an attractive solution to environmental sustainability and clean energy production. Here, the authors construct spin−polarized Fe₁−Ti pairs via manipulating oxygen vacancies on monolithic titanium electrode for highly efficient nitrate to ammonia conversion.

Together with an accompanying paper presenting a transcriptomic atlas of the mouse lemur, interrogation of the atlas provides a rich body of data to support the use of the organism as a model for primate biology and health.

Danish Saleheen, Benjamin Voight and colleagues perform genome-wide analysis of multi-ancestry cohorts to identify genetic associations with type 2 diabetes (T2D) and coronary heart disease (CHD). They find novel loci and show that 24% of T2D loci are also associated with CHD and that greater genetic risk of T2D increases risk of CHD.

Sparse labelling and whole-brain imaging are used to reconstruct and classify brain-wide complete morphologies of 1,741 individual neurons in the mouse brain, revealing a dependence on both brain region and transcriptomic profile.

The BRAIN Initiative Cell Census Network has constructed a multimodal cell census and atlas of the mammalian primary motor cortex in a landmark effort towards understanding brain cell-type diversity, neural circuit organization and brain function.

Mechanically switchable materials made of supercooled fluids embedded in a polymer matrix reversibly shift between soft and hard solid states upon stimulation.

Using multiple datasets from real-world evidence and completed trials, a machine learning model using routine blood and clinical data is shown to be predictive of patient response to immune checkpoint inhibitor therapy, across cancer types and outperforming standard biomarkers.

The flavouring, perfume and pharmaceutical industries rely on the selective hydrogenation of α,β-unsaturated aldehydes to generate unsaturated alcohols; here, a new type of highly selective catalyst is described in which platinum nanoparticles are sandwiched between a core and a shell of a metal−organic framework.

Ferroelectric HfO₂ is faced with an oxygen vacancy dilemma, which favors the polar phase but harm to switching behaviors. Here, the authors propose a donor-acceptor co-doping method to enhance polarization switching characteristics of the HfO₂ films.

Elucidation of the fundamental mechanisms behind the dynamic chirality inversion of supramolecular assemblies with pathway complexity is challenging. Here, the authors report metal coordination driven assembly systems based on pyridyl-conjugated cholesterol and show that metal ions facilitate pathway-directed, recyclable chirality inversion and assembly polymorphism.

The molecular mechanisms underlying the transformation of Chronic Myeloid Leukaemia (CML) from chronic phase (CP) to blast crisis (BC) are not completely elucidated. Here, the authors show that acquired miR-142 deficiency drives CML BC by regulating mitochondrial metabolism and is a potential therapeutic target to prevent BC in CML murine models.

The authors demonstrate that high-pressure treatment of IPA endows the material with enhanced hydrogen bonding, which brightens the white-light emission by regulating the ratio of singlet and triplet exciton populations.

Transforming the energy system to achieve net-zero carbon emissions by 2100 is vital to fight climate change. This target can be achieved in California, USA, by 2050—alongside air quality benefits especially in disadvantaged communities—by using bioenergy with carbon capture and sequestration.

Large genome-wide meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism.

Histopathological analysis is an essential tool in diagnosing colorectal cancer, but is limited in predicting prognosis and molecular profiles. Here, the authors designed a machine learning-based platform to predict multi-omics profiles and prognosis from pathology images.

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

The genome of the flying spider-monkey tree fern and investigations on stem formation and secondary metabolite biosynthesis promote our understanding of fern evolution and arborescence, facilitating the protection and utilization of this endangered species.