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Showing 1–3 of 3 results
Advanced filters: Author: Kwok-Ho Chan Clear advanced filters

  • The description of the crystal structure of the Brd4 PROTAC compound MZ1 in complex with the human E3 ubiquitin ligase VHL and the Brd4 bromodomain shines new light onto how PROTACs work and enables design of degraders with increased selectivity for Brd4.

    • Morgan S Gadd
    • Andrea Testa
    • Alessio Ciulli
    Research
    Nature Chemical Biology
    Volume: 13, P: 514-521

  • Trivalent PROTACs are reported as a strategy to increase protein degradation efficacy and therapeutic window by combining avidity of target engagement with cooperativity to form highly favorable and productive ternary complexes.

    • Satomi Imaide
    • Kristin M. Riching
    • Alessio Ciulli
    Research
    Nature Chemical Biology
    Volume: 17, P: 1157-1167