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Communications Biology (1)

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Evolutionary conservation of ubiquitin-like protein urmylation as revealed by URM1 gene shuffle from archaea to yeast

URM1 gene shuffle from S. acidocaldarius to S. cerevisiae has uncovered that dual-functional sulfur carrier roles for Urm1 in tRNA thiolation and protein urmylation can be separated from one another by expressing an archaeal Urm1 homolog in yeast.

Katharina Zupfer
Lars Kaduhr
Raffael Schaffrath
ResearchOpen Access23 Nov 2025
Communications Biology

Volume: 8, P: 1-8

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Evolutionary conservation of ubiquitin-like protein urmylation as revealed by URM1 gene shuffle from archaea to yeast

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