Treg control the magnitude of immune responses, but how these cells are controlled is less understood. Here the authors show that a transcriptional repressor YY1 inhibits Foxp3, the master regulator of Treg, by repressing its transcription, and by directly interacting with Foxp3 and its target gene promoters.
- Soo Seok Hwang
- Sung Woong Jang
- Gap Ryol Lee
