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Advanced filters: Author: Lars von Buchholtz Clear advanced filters

  • Functional imaging and multiplexed in situ hybridization were combined to investigate how trigeminal neurons encode heat and mechanical stimuli, revealing distinct cellular mechanisms for continuing pain, heat hypersensitivity and tactile allodynia during inflammation.

    • Nima Ghitani
    • Lars J. von Buchholtz
    • Alexander T. Chesler
    ResearchOpen Access
    Nature
    Volume: 642, P: 1016-1023

  • High concentrations of salt activate sour- and bitter-taste-sensing cells in the tongues of mice, and genetic silencing of these pathways abolishes behavioural aversion to concentrated salt; this ‘co-opting’ of the two primary aversive taste pathways (sour and bitter) may have evolved so that high salt levels reliably trigger behavioural rejection.

    • Yuki Oka
    • Matthew Butnaru
    • Charles S. Zuker
    Research
    Nature
    Volume: 494, P: 472-475