Nature Search

GAK and PRKCD are positive regulators of PRKN-independent mitophagy

The mechanisms involved in programmed or damage-induced removal of mitochondria by mitophagy remain elusive. Here the authors use an siRNA library to screen lipid-binding proteins, and identify the kinases GAK and PRKCD as positive regulators of PRKN-independent mitophagy.

Michael J. Munson
Benan J. Mathai
Anne Simonsen
ResearchOpen Access20 Oct 2021
Nature Communications

Volume: 12, P: 1-22
News media coverage of COVID-19 public health and policy information

Katharine J. Mach
Raúl Salas Reyes
Nicole Klenk
ResearchOpen Access28 Sept 2021
Humanities and Social Sciences Communications

Volume: 8, P: 1-11
Machine learning identifies clusters of multimorbidity among decedents with inflammatory bowel disease

Postill et al. apply unsupervised machine learning methods to cluster longitudinal administrative health data of deceased people with IBD. Their model identifies three clusters of multimorbidity present at death among those with IBD: mood disorder and/or osteo- and other arthritis; cancer and low multimorbidity; and cardiovascular comorbidities.

Gemma Postill
Vinyas Harish
Eric I. Benchimol
ResearchOpen Access18 Nov 2025
Communications Medicine

Volume: 5, P: 1-14
Targeting mitophagy in neurodegenerative diseases

Impaired mitophagy leading to the accumulation of damaged mitochondria is associated with the onset and progression of neurodegenerative diseases. This Review provides an overview of the molecular pathways of mitophagy regulation in neurons, discusses evidence implicating mitophagy impairment in the pathogenesis of neurodegenerative diseases and assesses small-molecule-based therapeutic approaches aimed at selective mitophagy enhancement.

Odetta Antico
Paul W. Thompson
Laura E. Parton
Reviews14 Jan 2025
Nature Reviews Drug Discovery

Volume: 24, P: 276-299
Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry

Personalized medicine requires accurate and ethnicity-optimized reference genome panels. Here, the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) evaluates typical variant filters and existing genome databases against newly sequenced African-ancestry populations.

Michael D. Kessler
Laura Yerges-Armstrong
Timothy D. O’Connor
ResearchOpen Access11 Oct 2016
Nature Communications

Volume: 7, P: 1-8
Sense of belonging to community and avoidable hospitalization: a population-based cohort study of 456,415 Canadians

Mindy Lu
Sarah M. Mah
Laura C. Rosella
ResearchOpen Access10 Sept 2024
Scientific Reports

Volume: 14, P: 1-11
Predicting adverse outcomes due to diabetes complications with machine learning using administrative health data

Mathieu Ravaut
Hamed Sadeghi
Laura Rosella
ResearchOpen Access12 Feb 2021
npj Digital Medicine

Volume: 4, P: 1-12
Prognostic Relevance of Mitotic Activity in Patients with Node-Negative Breast Cancer

Laura Medri
Annalisa Volpi
Rosella Silvestrini
Research01 Nov 2003
Modern Pathology

Volume: 16, P: 1067-1075
Depression-related weight change and incident diabetes in a community sample

Eva Graham
Tristan Watson
Norbert Schmitz
ResearchOpen Access30 Jun 2021
Scientific Reports

Volume: 11, P: 1-10
Glial degeneration with oxidative damage drives neuronal demise in MPSII disease

Cristina Zalfa
Chiara Verpelli
Lidia De Filippis
ResearchOpen Access11 Aug 2016
Cell Death & Disease

Volume: 7, P: e2331

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